LPYFD-NH2 Trifluoroacetic Acid Salt

CAS: 700361-48-4

Rif. TR-L473400

Informazioni sul prodotto

• Nome: LPYFD-NH2 Trifluoroacetic Acid Salt
• Sinonimi: L-Leucyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-alpha-asparagine Trifluoroacetic Acid Salt, Leu-Pro-Tyr-Phe-Asp-NH2 TFA

Descrizione

Applications LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). LPYFD-NH2 protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. LPYFD-NH2 is a potential therapeutic in the treatment of Alzheimer's Disease.
References Wisniewski, T., et al.: Neurobiol. Dis., 4, 313 (1997), Wang, J., et al.: Exp. Neurol., 158, 328 (1999), Dahlgren, K., et al.: J. Biol. Chem. 277, 32046 (2002), Forman, M., et al.: Neurology, 68, 757 (2007),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 766.761
• Formula: C₃₅H₄₅F₃N₆O₁₀
• Colore/Forma: White SOlid
• InChI: InChI=1S/C33H44N6O8.C2HF3O2/c1-19(2)15-23(34)33(47)39-14-6-9-27(39)32(46)38-26(17-21-10-12-22(40)13-11-21)31(45)37-25(16-20-7-4-3-5-8-20)30(44)36-24(29(35)43)18-28(41)42;3-2(4,5)1(6)7/h3-5,7-8,10-13,19,23-27,40H,6,9,14-18,34H2,1-2H3,(H2,35,43)(H,36,44)(H,37,45)(H,38,46)(H,41,42);(H,6,7)/t23-,24-,25-,26-,27+;/m0./s1
• InChI key: InChIKey=IXZJYLXIKGCIAF-AUFFENBXSA-N
• SMILES: CC(C)C[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O.O=C(O)C(F)(F)F