Met-enkephalin

CAS: 58569-55-4

Rif. TR-M225485

Informazioni sul prodotto

• Nome: Met-enkephalin
• Sinonimi: Human ß-Endorphin(1-5), L-Methionine-enkephalin, Lupex, Met5-enkephalin, Metenkefalin, Methionine Enkephalin, Methionyl-enkephalin, NSC 374896, Opioid Growth Factor, PN: US5961923 PAGE: 135 claimed protein, Peptid-M, 53: PN: US20090104234 SEQID: 53 unclaimed protein, 5: PN: US20080039404 SEQID: 5 unclaimed sequence, 6: PN: US20130072438 SEQID: 5 unclaimed sequence, 6: PN: WO0130371 TABLE: 1 unclaimed sequence, 707: PN: US20090175821 SEQID: 882 claimed protein, 7: PN: US20130303729 SEQID: 7 unclaimed protein, 7: PN: WO0130371 TABLE: 1 unclaimed sequence, 7: PN: WO2008106043 TABLE: 6 claimed protein, 9: PN: WO03061683 FIGURE: 1 unclaimed sequence, 9: PN: WO2004041151 SEQID: 9 unclaimed sequence, 5-L-Methionine-enkephalin, 5-Methionine Enkephalin, 105: PN: US20030119021 SEQID, 10: PN: WO2008008805 SEQID: 10 unclaimed protein, 153: PN: US20030176421 PAGE: 54-55 claimed protein, 16: PN: EP1498113 PAGE: 14 claimed protein, 25: PN: WO2005095443 SEQID: 25 claimed protein, 3: PN: WO2008052043 SEQID: 2 claimed protein, 46: PN: US6017496 PAGE: 120 claimed protein, 5-Methionine enkephalin, Adrenorphin (human), 6-de-L-arginine-7-de-L-arginine-8-de-L-valinamide-, Enkephalin, methionine, Human β-endorphin(1-5), Methionine enkephalin, N-[N-[N-(N-L-tirosilglicil)glicil]-L-fenilalanil]-L-metionina, N-[N-[N-(N-L-Tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionin, N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionine, Nsc 374896, Opioid growth factor, Porcine β-endorphin 1-5, Tyr-Gly-Gly-Phe-Met-OH, β-Endorphin(1-5)

Descrizione

Stability Unstable in alkaline solution
Applications Met-enkephalin is an endogenous opioid peptide that increases expression levels of δ, μ and κ-opioid receptors, inhibits growth, apoptosis and proliferation in human melanoma A375 cells. Antitumor effect via regulating dendritic cells. Regulation of the immune system, therapy effects of antitumor, autoimmune diseases, AIDS, and other immune-related diseases.
References Wang, D., et al.: Mol. Med. Rep., 14, 5521 (2016); Feng, P., et al.: Weishengwuxue Zazhi, 35, 100 (2015); Meng, Y., et al.: Int. Immunopharmacol., 44, 61 (2017)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 573.66
• Formula: C₂₇H₃₅N₅O₇S
• Colore/Forma: Neat
• InChI: InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1
• InChI key: InChIKey=YFGBQHOOROIVKG-UHFFFAOYSA-N
• SMILES: CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)O