O6-Methyl-2’-deoxyguanosine

CAS: 964-21-6

Rif. TR-M293040

Informazioni sul prodotto

• Nome: O6-Methyl-2’-deoxyguanosine
• Sinonimi: 2-Amino-9-(2-deoxy-ß-D-erythro-pentofuranosyl)-6-methoxy-9H-purine, 2-Amino-9-(2-deoxy-ß-D-ribofuranosyl)-6-methoxy-9H-purine, 2'-Deoxy-6-O-methylguanosine, 2'-Deoxy-6-methylguanosine, 2-Amino-6-methoxy-9-(2-deoxy-ß-D-erythro-pentofuranosyl)purine, 2'-Deoxy-O(6)-methylguanosine, 2-Amino-6-methoxy-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)purine, 2′-Deoxy-6-O-methylguanosine, 2′-Deoxy-6-methylguanosine, 6-O-Methyl-2′-deoxyguanosine, 6-O-Methyldeoxyguanosine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methoxy-9H-purin-2-amine, 9H-Purine, 2-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-6-methoxy-, 9H-Purine, 2-amino-9-(2-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-6-methoxy-, Guanosine, 2'-deoxy-6-O-methyl-, O(6)-Methyl-2'-deoxyguanosine, O(6)-Methyldeoxyguanosine, O⁶-Methyl-2′-deoxyguanosine, O⁶-Methyldeoxyguanosine, 9H-Purine, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxy-, 9H-Purine, 2-amino-9-(2-deoxy-β-D-ribofuranosyl)-6-methoxy-, 2-Amino-6-methoxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine

Descrizione

Applications O6-Methyl-2’-deoxyguanosine is a ubiquitous DNA lesion formed by xenobiotic carcinogens and endogenous methylating agent, S-adenosyl-L-methionine. A mutagenic adducts formed by a potent tobacco carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
References Patra, A., et al.: J. Biol. Chem., 291, 24304-24313 (2016); Gowda, A. S., et al.: Chem. Res. Toxicol., 29, 1894-1900 (2016)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 281.27
• Formula: C₁₁H₁₅N₅O₄
• Colore/Forma: Neat
• InChI: InChI=1S/C11H15N5O4/c1-19-10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15)/t5-,6+,7+/m0/s1
• InChI key: InChIKey=BCKDNMPYCIOBTA-RRKCRQDMSA-N
• SMILES: COc1nc(N)nc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1