1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one

CAS: 824932-89-0

Rif. TR-M331405

Informazioni sul prodotto

• Nome: 1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one
• Sinonimi: 3-(4-Hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-2-propen-1-one

Descrizione

Applications 1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one is an intermediate in synthesizing GFT-505 (G368870), which is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.
References Carious, B., et al.: Diabetes Care 36, 2923 (2013); Carious, B., et al.: Diabetes Care 34, 2008 (2011);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 298.4
• Formula: C₁₈H₁₈O₂S
• Colore/Forma: Neat
• InChI: InChI=1S/C18H18O2S/c1-12-10-14(11-13(2)18(12)20)4-9-17(19)15-5-7-16(21-3)8-6-15/h4-11,20H,1-3H3/b9-4+
• InChI key: InChIKey=PHRSDLZWVTXEOY-RUDMXATFSA-N
• SMILES: CSc1ccc(C(=O)/C=C/c2cc(C)c(O)c(C)c2)cc1