MK-2048

CAS: 869901-69-9

Rif. TR-M425030

Informazioni sul prodotto

• Nome: MK-2048
• Sinonimi: (6S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide
• CAS: 869901-69-9

Descrizione

Applications MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
References Tamara, B.M. et al.: J. Virol., 10, 1128 (2010);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 461.87
• Formula: C₂₁H₂₁ClFN₅O₄
• Colore/Forma: Light Yellow to Yellow Solid
• InChI: InChI=1S/C21H21ClFN5O4/c1-4-26-8-10(2)28-16-14(18(29)17(28)21(26)32)20(31)27(25-15(16)19(30)24-3)9-11-5-6-13(23)12(22)7-11/h5-7,10,29H,4,8-9H2,1-3H3,(H,24,30)/t10-/m0/s1
• InChI key: InChIKey=JSRREMIKIHJGAA-JTQLQIEISA-N
• SMILES: CCN1C[C@H](C)n2c(c(O)c3c(=O)n(Cc4ccc(F)c(Cl)c4)nc(C(=O)NC)c32)C1=O