Informazioni sul prodotto
Nome:
NO-Aspirin 1
Sinonimi:
- 2-Acetyloxybenzoic Acid 3-Nitrooxymethylphenyl Ester
- 2-(Acetyloxy)-3-[(Nitrooxy)Methyl]Phenyl Ester, Benzoic Acid
- 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester
- 2-AcetyloxybenzoicAcid3-NitrooxymethylphenylEster
- 3-((Nitrooxy)methyl)phenyl 2-acetoxybenzoate
- 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate
- 3-[(Nitrooxy)Methyl]Phenyl 2-(Acetyloxy)Benzoate
- Benzoic acid, 2-(acetyloxy)-, 3-[(nitrooxy)methyl]phenyl ester
- Ncx 4016
- Nitroaspirin
- Vedi altri sinonimi
Descrizione:
Applications NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.
References Wallace, J.F., et al.: Drug Development Res., 42, 144 (1997), Takeuchi, K, et al.: J. Physiol. Pharmacol., 49, 501 (1998), Bak, A.W., et al.: Life Sci., 62, 367 (1998), Wallace, J.L., et al.: Nature Reviews Drug Discovery, 1, 375 (2002), Chiroli, V., et al.: Eur. J. Med. Chem., 38, 441 (2003)
Avviso:
I nostri prodotti sono destinati esclusivamente ad uso di laboratorio. Per qualsiasi altro utilizzo, vi preghiamo di contattarci.
Marchio:
TRC
Conservazione lunga:
Note:
Proprietà chimiche
Peso molecolare:
331.28
Formula:
C16H13NO7
Colore/Forma:
White to Off-White Solid
InChI:
InChI=1S/C16H13NO7/c1-11(18)23-15-9-5-3-7-13(15)16(19)24-14-8-4-2-6-12(14)10-22-17(20)21/h2-9H,10H2,1H3
SMILES:
CC(=O)Oc1ccccc1C(=O)Oc1cccc(CO[N+](=O)[O-])c1
MDL:
Punto di fusione:
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