Tetraethyl Fluorescein Bis(methylene)bis(azanetriyl)tetraacetate
CAS: 1170856-93-5
Rif. TR-T292720
100mg | 423,00 € |
Informazioni sul prodotto
- Tetraethyl 2,2’,2’’,2’’’-(((3’,6’-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9’-xanthene]-4’,5’-diyl)bis(methylene))bis(azanetriyl))tetraacetate
Applications Tetraethyl Fluorescein Bis(methylene)bis(azanetriyl)tetraacetate is an intermediate used in the synthesis of Calcein AM (C125400), which is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein (sc-202090), which is an extremely fluorescent and negatively charged molecule. Calcein-AM can be used to stain living cells and in cytoplasmic Schwann cells has been observed to fluoresce bright green. Calcein-AM has been reported to be a neutral substrate for P-glycoprotein (Pgp) and multidrug resistance protein (MRP) and has been used in flow cytometry studies to analyze the function of P-gp and MRP.
References Feller, N., et al.: Br. J. Cancer, 72, 543 (1995); Dhar, S., et al.: Eur. J. Pharmacol., 346, 315 (1998); Essodaigui, M., et al.: Biochemistry, 37, 2243 (1998); Lemasters, J.J., et al.: Biochim. Biophys. Acta., 1366,177 (1998);
Proprietà chimiche
Richiesta tecnica su: TR-T292720 Tetraethyl Fluorescein Bis(methylene)bis(azanetriyl)tetraacetate
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