YM 201636

CAS: 371942-69-7

Rif. TR-Y100580

Informazioni sul prodotto

• Nome: YM 201636
• Sinonimi: 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide, Ym 201636
• CAS: 371942-69-7

Descrizione

Applications YM 201636 is a phosphatidylinositol phosphate kinase PIP5KIII (PIKfyve) inhibitor and significantly reduces the survival of primary mouse hippocampal neurons in culture. YM-201636 treatment increases the level of the autophagosomal marker protein LC3-II.
References Martin, S., et. al.: Plos One, 8, e60152 (2013)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 467.48
• Formula: C₂₅H₂₁N₇O₃
• Colore/Forma: Pale Beige to Light Beige Solid
• InChI: InChI=1S/C25H21N7O3/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17)22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32/h1-8,13-14H,9-12H2,(H2,26,28)(H,29,33)
• InChI key: InChIKey=YBPIBGNBHHGLEB-UHFFFAOYSA-N
• SMILES: Nc1ccc(C(=O)Nc2cccc(-c3nc(N4CCOCC4)c4oc5ncccc5c4n3)c2)cn1