ELK Promotion

ERK5, Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment, to be specific, to decreases in oxygen, or hypoxia.This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding.

Transcriptional repressor. Involved in the generation and migration of neural crest cells.

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.

p53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro.

Autophagy marker Light Chain 3 (LC3) was originally identified as a subunit of microtubule-associated proteins 1A and 1B (termed MAP1LC3).

Glutamate is the major excitatory neurotransmitter and modulates its effects via ionotropic and metabotropic receptors which are different in their molecular, biochemical, pharmacological and physiological properties. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

The angiotensin-(1-7) Mas receptor is the recently identified receptor of the biologically active heptapeptide angiotensin-(1-7).Angiotensin (Ang)-(1-7) is a metabolite of the well known peptide hormone Angiotensin (Ang) II, a key component of the renin-angiotensin system (RAS) that has a central role in cardiovascular homeostasis.

The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Two different topologies for Bestrophin-1 have been proposed.

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death.

Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene.TLR 4 has also been designated as CD284. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes.

TLR13 is found in mouse and participates in the innate immune response to microbial agents. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281.

Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282. TLR2 is one of the toll-like receptors and plays a role in the immune system.

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene. TLR6 has also been designated as CD286.

Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288.

Receptor for neuromedin-B. Belongs to the G-protein coupled receptor 1 family.

Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization.

Calcium homeostasis modulator 1 (CALHM1) is a pore-forming membrane protein that in humans is encoded by the CALHM1 gene.