CAS 1009298-09-2

5-[2,4-Bis[(3S)-3-metil-4-morfolinil]pirido[2,3-d]pirimidin-7-il]-2-metoxibenzenometanol

Descrição:

5-[2,4-Bis[(3S)-3-metil-4-morfolinil]pirido[2,3-d]pirimidin-7-il]-2-metoxibenzenometanol, com número CAS 1009298-09-2, é um composto orgânico complexo caracterizado por sua estrutura de múltiplos anéis, que inclui um núcleo de pirido-pirimidina e um grupo benzeno substituído por metóxi. Este composto apresenta um grupo morfolina, contribuindo para sua potencial atividade biológica, particularmente em química medicinal. A presença de múltiplos grupos funcionais sugere que pode exibir diversas reatividades químicas e propriedades de solubilidade. Sua estereoquímica, indicada pela configuração (3S), implica arranjos espaciais específicos que podem influenciar sua interação com alvos biológicos. As potenciais aplicações do composto podem incluir papéis como agente farmacêutico, dadas suas características estruturais que muitas vezes estão associadas a moléculas bioativas. No entanto, estudos detalhados sobre sua farmacocinética, toxicidade e eficácia seriam necessários para entender completamente suas características e potenciais usos em contextos terapêuticos.

Fórmula: C₂₅H₃₁N₅O₄

InChI: InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1

Chave InChI: InChIKey=KVLFRAWTRWDEDF-IRXDYDNUSA-N

SMILES: C[C@@H]1N(C=2C3=C(N=C(N2)N4[C@@H](C)COCC4)N=C(C=C3)C5=CC(CO)=C(OC)C=C5)CCOC1

Sinónimos:

• 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
• Azd 8055
• Azd8055
• Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-
• Ccg 168
• Lm1148
• Nvp-Ccg 168
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD 8055
• AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• (5-{2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
• AZD8055,AZD-8055
• AZD8055, >=98%
• {5-[2,4-Bis-(3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol
• AZD-8055 USP/EP/BP
• [5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[
• (5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate
• AZD-8055; AZD8055; AZD 8055.
• Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester
• CS-1935

Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-

CAS: 1009298-09-2

Fórmula: C₂₅H₃₁N₅O₄

Pureza: 96%

Cor e Forma: Solid

Peso molecular: 465.5447

Ref: IN-DA000383

AZD-8055

CAS: 1009298-09-2

AZD-8055

Pureza: ≥95%

Peso molecular: 465.54g/mol

Ref: 54-BUP13178

Azd-8055

CAS: 1009298-09-2

Azd-8055

Pureza: 97%

Peso molecular: 465.54g/mol

Ref: 54-OR1024083

AZD-8055

CAS: 1009298-09-2

AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.

Fórmula: C₂₅H₃₁N₅O₄

Pureza: 98% - 99.69%

Cor e Forma: Solid

Peso molecular: 465.54

Ref: TM-T1859

AZD-8055

CAS: 1009298-09-2

Pureza: ≥ 95.0%

Cor e Forma: Yellow powder or solid

Ref: 7W-GW4102

AZD8055

Produto Controlado

CAS: 1009298-09-2

Applications A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Dual mTORC1/C2 inhibitor
References Chresta, C.M. et al.: Cancer Res., 70, 288 (2010); Sini, P. et al. Autophagy., 6 (2010); Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2011);

Fórmula: C₂₅H₃₁N₅O₄

Cor e Forma: Neat

Peso molecular: 465.54

Ref: TR-A808130

AZD 8055

CAS: 1009298-09-2

A selective and ATP-competitive inhibitor of mTOR kinase with an IC50 value of 0.8 nM. Inhibits growth of a range of tumor types in vivo and in vitro. Effective in preventing and treating endocrine-resistant breast cancer. Causes autophagy in H838 and A549 cells.

Fórmula: C₂₅H₃₁N₅O₄

Pureza: Min. 95%

Peso molecular: 465.54 g/mol

Ref: 3D-FA18068