CAS 1009307-40-7

2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione

Produto Controlado

CAS: 1009307-40-7

Applications 2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of Lapatinib-d7 Dihydrochloride (L175807), which is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic;Also, it is used in the preparation of 4-Aminoquinazolines as EGFR and HER-2 inhibitors.
References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005); Tung, R.: PCT Int. Appl. (2008), WO 2008024439 A2 20080228

Fórmula: C₁₁D₇H₄NO₂S

Cor e Forma: Neat

Peso molecular: 228.319

Ref: TR-M332347