CAS 1025821-33-3

GSK-626616

CAS: 1025821-33-3

GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.

Fórmula: C₁₈H₁₀Cl₂N₄OS

Pureza: 98.27%

Cor e Forma: Solid

Peso molecular: 401.27

Ref: TM-T15422

(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone

CAS: 1025821-33-3

Fórmula: C₁₈H₁₀Cl₂N₄OS

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 401.2692

Ref: IN-DA01ENHC

GSK-626616

CAS: 1025821-33-3

GSK-626616

Pureza: ≥98%

Peso molecular: 401.27g/mol

Ref: 54-BUP04439

GSK 626616

CAS: 1025821-33-3

Potent inhibitor of dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) with IC50 value of 0.7 nM. Elevates hemoglobin and platelet levels in anemic mice.

Fórmula: C₁₈H₁₀Cl₂N₄OS

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 401.27 g/mol

Ref: 3D-BG166664

GSK 626616 - Bio-X ™

CAS: 1025821-33-3

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₈H₁₀Cl₂N₄OS

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 401.27 g/mol

Ref: 3D-BG300011

GSK-626616

Produto Controlado

CAS: 1025821-33-3

Applications GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
References Wippich, Frank., et al.: Cell., 152, 791(2013); Corona, John A., et al.: Org. Process Res. Dev., 14, 712 (2010)

Fórmula: C₁₈H₁₀Cl₂N₄OS

Cor e Forma: Yellow

Peso molecular: 401.27

Ref: TR-G797853