CAS 103129-82-4

(-)-Amlodipina

Descrição:

(-)-Amlodipina é um bloqueador de canais de cálcio usado principalmente no tratamento da hipertensão e angina. É um derivado de dihidropiridina, caracterizado por sua capacidade de inibir seletivamente a entrada de íons de cálcio através dos canais de cálcio tipo L no músculo liso vascular e no músculo cardíaco. Essa ação leva à vasodilatação, reduzindo a resistência vascular periférica e diminuindo a pressão arterial. O composto é tipicamente administrado na forma de sal de besilato, o que melhora sua solubilidade e biodisponibilidade. (-)-Amlodipina é conhecido por sua longa meia-vida, permitindo a dosagem uma vez ao dia, e apresenta uma mistura racêmica, com o enantiômero (-) sendo a forma ativa. Sua estrutura molecular inclui um anel de 1,4-dihidropiridina, um grupo fenila e um moiety de piperidina, contribuindo para suas propriedades farmacológicas. Efeitos colaterais comuns podem incluir edema periférico, dor de cabeça e fadiga. Assim como com qualquer medicamento, é essencial considerar contraindicações e interações com outros medicamentos ao prescrever (-)-Amlodipina.

Fórmula: C₂₀H₂₅ClN₂O₅

InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1

Chave InChI: InChIKey=HTIQEAQVCYTUBX-KRWDZBQOSA-N

SMILES: C(OCC)(=O)C=1[C@H](C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2

Sinónimos:

• (-)-Amlodipine
• (4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
• 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-
• 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (S)-
• 3-Ethyl 5-methyl (4S)-2-((2-aminoethoxy)methyl)-4-(2-
• 3-ethyl 5-methyl (4R)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate (1:1)
• 3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• Levamlodipine
• Levamlodipine besylate
• Levoamlodipine
• Levoamlodipine Besylate
• Lodien
• chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• l-Amlodipine

Levamlodipine (3-ethyl 5-methyl (S)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate)

CAS: 103129-82-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₂₀H₂₅ClN₂O₅

Cor e Forma: Off-White Solid

Peso molecular: 408.1452

Ref: 45-1A01960

(4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

CAS: 103129-82-4

Fórmula: C₂₀H₂₅ClN₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 408.8759

Ref: IN-DA00327Q

Levamlodipine

CAS: 103129-82-4

Levamlodipine (S-amlodipine) belongs to the dihydropyridine group of calcium channel blockers.

Fórmula: C₂₀H₂₅ClN₂O₅

Pureza: 97.21%

Cor e Forma: White Crystal Powder

Peso molecular: 408.88

Ref: TM-T1545

Levamlodipine

CAS: 103129-82-4

Levamlodipine

Pureza: ≥95%

Peso molecular: 408.88g/mol

Ref: 54-BUP15737

(S)-Amlodipine

CAS: 103129-82-4

(S)-Amlodipine

Pureza: 99%

Peso molecular: 408.88g/mol

Ref: 54-OR1024552

(S)-Amlodipine

CAS: 103129-82-4

Fórmula: C₂₀H₂₅ClN₂O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 408.88

Ref: 4Z-A-085

(S)-Amlodipine

CAS: 103129-82-4

Fórmula: C₂₀H₂₅ClN₂O₅

Pureza: >97.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 408.88

Ref: 3B-A3608

(S)-Amlodipine

Produto Controlado

CAS: 103129-82-4

Applications (S)-Enantiomer of Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995),

Fórmula: C₂₀H₂₅ClN₂O₅

Cor e Forma: Neat

Peso molecular: 408.88

Ref: TR-A633491

Levamlodipine

CAS: 103129-82-4

Levamlodipine is a calcium channel blocker that is used to treat hypertension or high blood pressure. It prevents the entry of calcium into the cell by blocking voltage-gated calcium channels. Levamlodipine has been shown to be safe and effective in lowering blood pressure in patients with hypertension. The drug is not metabolized and can be detected in the blood for up to 24 hours after administration. Levamlodipine besylate, the active form of levamlodipine, is converted into its active form by esterases and glucuronidases in the liver and kidneys. This conversion takes place at a constant rate, resulting in a concentration–time curve that can be described using mathematical models.

Fórmula: C₂₀H₂₅ClN₂O₅

Pureza: Min. 95%

Cor e Forma: Solid

Peso molecular: 408.88 g/mol

Ref: 3D-FL174858