CAS 104344-23-2

Fumarato de bisoprolol

Descrição:

Fumarato de bisoprolol é um bloqueador seletivo do receptor adrenérgico beta-1, utilizado principalmente no manejo da hipertensão e insuficiência cardíaca. É um pó cristalino branco a branco amarelado que é solúvel em água e metanol, mas menos solúvel em solventes orgânicos como clorofórmio e éter. A substância é caracterizada por sua capacidade de reduzir a frequência cardíaca e a contratilidade miocárdica, tornando-a eficaz na redução da pressão arterial e na melhoria da função cardíaca. Fumarato de bisoprolol é tipicamente administrado por via oral e é conhecido por sua meia-vida relativamente longa, permitindo a dosagem uma vez ao dia. A forma de sal de fumarato melhora sua estabilidade e solubilidade, facilitando uma melhor absorção no trato gastrointestinal. Assim como outros beta-bloqueadores, pode ter efeitos colaterais como fadiga, tontura e bradicardia, e deve ser usado com cautela em pacientes com asma ou certas condições cardiovasculares. No geral, Fumarato de bisoprolol é um agente terapêutico importante na medicina cardiovascular, contribuindo para a melhoria dos resultados dos pacientes em várias condições relacionadas ao coração.

Fórmula: C₁₈H₃₁NO₄C₄H₄O₄

InChI: InChI=1S/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

Chave InChI: InChIKey=RZPZLFIUFMNCLY-WLHGVMLRSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(COCCOC(C)C)C=C1.C(=C/C(O)=O)\C(O)=O

Sinónimos:

• (2R)-1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol
• 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (salt)
• 1-(Propan-2-Ylamino)-3-(4-{[2-(Propan-2-Yloxy)Ethoxy]Methyl}Phenoxy)Propan-2-Ol
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1) (salt)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt)
• Bisoprolol Fumarate
• Bisoprolol fumerate
• Concor
• Detensiel
• Emcor
• Emd 33512
• Emvoncor
• Eurtadal
• Isoten
• Maintate
• Monocor
• Soprol

Bisoprolol Hemifumarate

CAS: 104344-23-2, 66722-44-9

Fórmula: C₁₈H₃₁NO₄C₄H₄O₄

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 383.49

Ref: 3B-B3994

Bisoprolol Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 104344-23-2

Cor e Forma: Single Solution

Ref: 61-AMP0460.08-01

Bisoprolol Fumarate

CAS: 104344-23-2

Cor e Forma: Neat

Ref: 61-FOR0460.08

BISOPROLOL FOR SYSTEM SUITABILITY CRS

CAS: 104344-23-2

BISOPROLOL FOR SYSTEM SUITABILITY CRS

Fórmula: C₄₀H₆₆N₂O₁₂

Cor e Forma: Added Added

Peso molecular: 766.9582

Ref: 41-Y0000813

Bisoprolol fumarate

CAS: 104344-23-2

Bisoprolol fumarate

Fórmula: (C₁₈H₃₁NO₄)₂C₄H₄O₄

Pureza: 99.7%

Cor e Forma: White

Peso molecular: 766.46158

Ref: 47-1058

BISOPROLOL FUMARATE CRS

CAS: 104344-23-2

BISOPROLOL FUMARATE CRS

Fórmula: C₄₀H₆₆N₂O₁₂

Cor e Forma: Added Added

Peso molecular: 766.9582

Ref: 41-Y0000812

BISOPROLOL FOR PEAK IDENTIFICATION CRS

CAS: 104344-23-2

BISOPROLOL FOR PEAK IDENTIFICATION CRS

Cor e Forma: Added Added

Ref: 41-Y0000877

Bisoprolol Fumarate

CAS: 104344-23-2

Aromatic drugs of amino-alcohols, other than those contg more than one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Fórmula: (C₁₈H₃₁NO₄)₂·C₄H₄O₄

Cor e Forma: White Powder

Peso molecular: 650.45062

Ref: 45-1075757

Bisoprolol (hemifumarate)

CAS: 104344-23-2

Fórmula: C₄₀H₆₆N₂O₁₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 766.9582

Ref: IN-DA003271

Bisoprolol hemifumarate

CAS: 104344-23-2

Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart,

Fórmula: C₂₀H₃₃NO₆

Pureza: 98.69% - 99.84%

Cor e Forma: White To Offf-White Powder

Peso molecular: 383.49

Ref: TM-T0143

Bisoprolol hemifumarate salt

CAS: 104344-23-2

Fórmula: C₁₈H₃₁NO₄₀·5C₄H₄O₄

Pureza: 98.0 - 102.0 %

Cor e Forma: White to almost white powder

Peso molecular: 383.49

Ref: 7W-GP0667

Bisoprolol Hemifumarate

CAS: 104344-23-2

Fórmula: C₁₈H₃₁NO₄·5C₄H₄O₄

Cor e Forma: White To Off-White Solid

Peso molecular: 325.45 0.5*116.07

Ref: 4Z-B-092

(±)-Bisoprolol-d7 Hemifumarate(iso-propyl-d7)

CAS: 104344-23-2

Pureza: 99 atom % D

Cor e Forma: White Solid

Peso molecular: 390.5

Ref: 3U-D7507

Bisoprolol fumarate

CAS: 104344-23-2

Fórmula: C₁₈H₃₁NO₄·C₄H₄O₄

Cor e Forma: Neat

Peso molecular: 766.9582

Ref: 04-C10654000

Bisoprolol Fumarate

CAS: 104344-23-2

Cor e Forma: Neat

Ref: 86-MM0460.08

Bisoprolol hemifumarate

Produto Controlado

CAS: 104344-23-2

Bisoprolol hemifumarate is a selective beta-1 receptor blocker that has been used in the treatment of high blood pressure, heart failure, and other cardiovascular diseases. It is a prodrug that undergoes enzymatic hydrolysis to bisoprolol in the liver. Bisoprolol hemifumarate has been shown to be effective as an adjunctive therapy for patients with bowel disease and cardiac effects such as lowering blood pressure levels. This drug also has a positive effect on the heart by increasing the levels of natriuretic peptides and decreasing the level of atrial fibrillation (AF). Bisoprolol hemifumarate can be detected in human serum or plasma samples through an analytical method involving liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS), which can then be analyzed by multivariate logistic regression to control for confounding factors such as age, gender, ethnicity, alcohol intake, and smoking status.

Fórmula: C₁₈H₃₁NO₄•(C₄H₄O₄)₀

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 383.48 g/mol

Ref: 3D-FB18827

Bisoprolol hemifumarate - Bio-X ™

Produto Controlado

CAS: 104344-23-2

Bisoprolol is a β1- adrenergic antagonist agent that is used to treat hypertension and prevent myocardial infarction. As adrenergic neurotransmitters activate β1-receptors it causes an increase in blood pressure and heart rate. By reducing contractility and the need for oxygen through competitive inhibition of β1-adrenergic receptors, bisoprolol reduces the cardiac workload.

Fórmula: C₁₈H₃₁NO₄C₄H₄O₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 383.48 g/mol

Ref: 3D-BB164256

Bisoprolol Hemifumarate

CAS: 104344-23-2

Applications A selective β-adrenergic blocker. Used as an antihypertensive.
References Tattersfield, A.E., et al.: Brit. J. Clin. Pharmacol., 18, 343 (1984), Kohli, R.S., et al.: Eur. Heart J., 6, 845 (1985), Zachariah, P.K., et al.: Clin. Ther., 15, 779 (1993),

Fórmula: C₁₈H₃₁NO₄·C₄H₄O₄

Cor e Forma: Neat

Peso molecular: 766.9582

Ref: TR-B510500

Bisoprolol for peak identification CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000877

Bisoprolol for system suitability CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000813