CAS 104594-70-9

Éster fenetílico do ácido cafeico

Descrição:

Éster fenetílico do ácido cafeico (CAPE) é um composto fenólico derivado do ácido cafeico, conhecido por suas potenciais propriedades antioxidantes, anti-inflamatórias e anticancerígenas. É um sólido marrom-amarelado à temperatura ambiente e é solúvel em solventes orgânicos como etanol e dimetilsulfóxido, mas tem solubilidade limitada em água. O CAPE exibe uma fórmula molecular que reflete sua estrutura, que inclui um grupo fenetila ligado à espinha dorsal do ácido cafeico. Este composto é frequentemente estudado por suas atividades biológicas, incluindo sua capacidade de inibir várias enzimas e modular vias de sinalização, tornando-o de interesse na pesquisa farmacológica. O CAPE foi investigado por seus efeitos protetores contra o estresse oxidativo e seu papel potencial na prevenção de doenças crônicas. Além disso, é reconhecido por sua capacidade de interagir com componentes celulares, influenciando processos como apoptose e proliferação celular. No geral, Éster fenetílico do ácido cafeico é um composto significativo no campo de produtos naturais e química medicinal, com pesquisas em andamento sobre suas aplicações terapêuticas.

Fórmula: C₁₇H₁₆O₄

InChI: InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2

Chave InChI: InChIKey=SWUARLUWKZWEBQ-UHFFFAOYSA-N

SMILES: C(=CC(OCCC1=CC=CC=C1)=O)C2=CC(O)=C(O)C=C2

Sinónimos:

• 2-Phenylethyl 3-(3,4-Dihydroxyphenyl)-2-Propenoate
• 2-Phenylethyl 3-(3,4-Dihydroxyphenyl)Prop-2-Enoate
• 2-Phenylethyl caffeate
• 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester
• 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• Caffeic acid phenethylester
• Phenethyl Caffeate
• β-Phenylethyl caffeate
• Caffeic acid phenethyl ester
• CAPE

Phenethyl Caffeate

CAS: 104594-70-9

Fórmula: C₁₇H₁₆O₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Orange to Green powder to crystal

Peso molecular: 284.31

Ref: 3B-P2088

Phenylethyl 3,4-dihydroxycinnamate, 98+%

CAS: 104594-70-9

Inhibitor of protein tyrosine kinase, and is cytotoxic to cancer cell lines

Fórmula: C₁₇H₁₆O₄

Pureza: 98+%

Peso molecular: 284.31

Ref: 02-J61386

Caffeic acid-phenethyl ester

CAS: 104594-70-9

CAPE is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulating properties. The molecular basis for these properties seems to be its ability to specifically and potently inhibit the activation of the nuclear transcription factor NF-kappaB.

Fórmula: C₁₇H₁₆O₄

Pureza: 99.4%

Cor e Forma: White Powder

Peso molecular: 284.31

Ref: 01-4027526

2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

CAS: 104594-70-9

Fórmula: C₁₇H₁₆O₄

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 284.3065

Ref: IN-DA00HADG

Caffeic acid phenethyl ester

CAS: 104594-70-9

Fórmula: C₁₇H₁₆O₄

Pureza: ≥ 98.0%

Cor e Forma: White to yellow crystalline powder

Peso molecular: 284.31

Ref: 7W-GK2776

Caffeic Acid Phenethyl Ester

CAS: 104594-70-9

Caffeic Acid Phenethyl Ester

Pureza: ≥98%

Peso molecular: 284.31g/mol

Ref: 54-BUP17813

Caffeic acid-phenylethyl ester

CAS: 104594-70-9

Fórmula: C₁₇H₁₆O₄

Cor e Forma: Neat

Peso molecular: 284.31

Ref: 04-C10934730

Caffeic acid phenethyl ester

CAS: 104594-70-9

Fórmula: C₁₇H₁₆O₄

Pureza: 95%~99%

Peso molecular: 284.311

Ref: BP-SBP03991

Caffeic Acid Phenethyl Ester

CAS: 104594-70-9

CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.

Fórmula: C₁₇H₁₆O₄

Pureza: 99.18% - 99.35%

Cor e Forma: Less Transparent Liquid Colorless Transparent Liquid

Peso molecular: 284.31

Ref: TM-T6429

Caffeic acid phenethyl ester

CAS: 104594-70-9

Caffeic acid phenethyl ester

Fórmula: C₁₇H₁₆O₄

Pureza: 98% (nmr) (Typical Value in Batch COA)

Cor e Forma: off-white solid

Peso molecular: 284.31g/mol

Ref: 54-BIB6022

Caffeic Acid Phenethyl Ester

CAS: 104594-70-9

Applications Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.
References Grunberger, D., et al.: Experientia, 44, 230 (1988), Fesen, M.R., et al.: Biochem. Pharmacol., 48, 595 (1994), Su, Z.Z., et al.: Cancer Res., 54, 1865 (1994), Zheng, Z.S., et al.: Oncol. Res., 7, 445 (1995), Mirzoeva, O.K. and Calder, P.C.: Essent. Fatty Acids, 55, 441 (1996)

Fórmula: C₁₇H₁₆O₄

Cor e Forma: Neat

Peso molecular: 284.31

Ref: TR-C080050

Caffeic acid phenethyl ester

CAS: 104594-70-9

Caffeic acid phenethyl ester (CAPE) is an active phenolic compound found in honeybee propolis that has the potential to downregulate inflammation in mammals. Studies demonstrated that CAPE specifically inhibits the protein complex NF-κB - a key player in inflammation, associated with the pathogenesis of chronic inflammatory diseases. Moreover, CAPE inhibits the activity of the enzyme cyclooxygenase and the production of nitric oxide by macrophages, also responsible for inflammation. By acting on T cells, CAPE can reduce the production of pro-inflammatory cytokines and increase the production of anti-inflammatory ones, leading to a less overwhelming immune response to allergens.

Fórmula: C₁₇H₁₆O₄

Pureza: Min. 98.0 Area-%

Peso molecular: 284.31 g/mol

Ref: 3D-C-1400

PHENETHYL CAFFEATE

CAS: 104594-70-9

Pureza: 97%

Peso molecular: 284.3110046

Ref: 10-F814395

Phenethyl 3-(3,4-dihydroxyphenyl)acrylate

CAS: 104594-70-9

Fórmula: C₁₇H₁₆O₄

Pureza: 95.0%

Cor e Forma: No data available.

Peso molecular: 284.311

Ref: 10-F212797