CAS 10540-29-1

Tamoxifeno

Descrição:

Tamoxifeno é um composto sintético não esteroidal usado principalmente no tratamento e prevenção do câncer de mama positivo para receptores de estrogênio. Funciona como um modulador seletivo de receptores de estrogênio (SERM), exibindo propriedades estrogênicas e antiestrogênicas dependendo do tecido-alvo. Quimicamente, Tamoxifeno é caracterizado por sua estrutura de bifenila, que permite que se ligue aos receptores de estrogênio, inibindo assim os efeitos do estrogênio no tecido mamário, enquanto potencialmente exerce efeitos semelhantes ao estrogênio em outros tecidos, como os ossos e o endométrio. Sua fórmula molecular é C26H29NO, e possui uma lipofilicidade relativamente alta, o que ajuda em sua absorção e distribuição no corpo. Tamoxifeno é tipicamente administrado por via oral e é conhecido por seus efeitos colaterais, que podem incluir ondas de calor, risco de eventos tromboembólicos e possíveis alterações endometriais. Devido ao seu mecanismo de ação, Tamoxifeno tem sido um pilar na terapia do câncer de mama, particularmente para mulheres pré-menopáusicas, e continua sendo objeto de pesquisa por suas implicações mais amplas no tratamento e prevenção do câncer.

Fórmula: C₂₆H₂₉NO

InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-

Chave InChI: InChIKey=NKANXQFJJICGDU-QPLCGJKRSA-N

SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3

Sinónimos:

• (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
• 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
• 2-{4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
• 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
• 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
• Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-
• Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
• Genox
• Ici 47699
• Kessar
• Mammaton
• Nolvadex
• Nolvadex-D
• Novaldex
• Tamoxen
• Tamoxifen Free Base
• Tamoxifen and its salts
• Tamoxifene
• Tamoxifeno
• Z-Tamoxifen

Tamoxifen Citrate

CAS: 10540-29-1, 54965-24-1

Fórmula: C₂₆H₂₉NO·C₆H₈O₇

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 563.65

Ref: 3B-T2510

Tamoxifen, 98%

CAS: 10540-29-1

Tamoxifen, 10540-29-1, is an antineoplastic agent that acts by competitively binding estrogen receptors to reduce DNA synthesis. Learn more at Thermo Fisher Scientific.

Fórmula: C₂₆H₂₉NO

Pureza: 98%

Cor e Forma: Powder, White to pale cream

Peso molecular: 371.52

Ref: 02-J63509

Tamoxifen

CAS: 10540-29-1

Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.

Fórmula: C₂₆H₂₉NO

Pureza: 98.46% - 99.92%

Cor e Forma: Fine Off-White Crystalline Powder

Peso molecular: 371.51

Ref: TM-T6906

Tamoxifen

CAS: 10540-29-1

Fórmula: C₂₆H₂₉NO

Pureza: ≥ 99.0%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 371.52

Ref: 7W-GA9513

Tamoxifen-d5 (ethyl-d5)(

CAS: 10540-29-1, 157698-32-3

Pureza: 98 atom % D

Cor e Forma: White Solid

Peso molecular: 376.55

Ref: 3U-D6637

Tamoxifen EP Impurity F-d5 HCl (N-Desmethyl Tamoxifen-d5 HCl)

CAS: 10540-29-1

Fórmula: C₂₅H₂₂D₅NO·HCl

Peso molecular: 362.53 36.46

Ref: 4Z-T-012

Tamoxifen

Produto Controlado

CAS: 10540-29-1

Fórmula: C₂₆H₂₉NO

Cor e Forma: Yellow

Peso molecular: 371.52

Ref: TR-T006000

Tamoxifen

Produto Controlado

CAS: 10540-29-1

Estrogen receptor modulator; protein kinase C inhibitor

Fórmula: C₂₆H₂₉NO

Pureza: Min. 90%

Cor e Forma: White Powder

Peso molecular: 371.51 g/mol

Ref: 3D-FT27994

Tamoxifen - Bio-X ™

Produto Controlado

CAS: 10540-29-1

Tamoxifen is used as an antineoplastic agent in the treatment of breast cancer. Tamoxifen has been shown to be a competitive antagonist at the estrogen receptor, preventing estrogen from binding and activating it. 
Tamoxifen is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₆H₂₉NO

Pureza: (%) Min. 95%

Cor e Forma: Powder

Peso molecular: 371.51 g/mol

Ref: 3D-BT164438

Tamoxifen (1 mg/mL in Methanol)

Produto Controlado

CAS: 10540-29-1

Fórmula: C₂₆H₂₉NO

Cor e Forma: Colourless

Peso molecular: 371.52

Ref: TR-KIT8260

trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine

Produto Controlado

CAS: 10540-29-1

2,4-Diphenyl-1-butenylphenoxyN,N-dimethylethylamine (2DPB) is a natural compound that has been shown to have cytotoxic effects in breast cancer cell lines. 2DPB is a selective estrogen receptor modulator (SERM) that binds to the estrogen receptor and alters its shape, which blocks the binding of estrogens. 2DPB has also been shown to have antiestrogenic activity in human breast cancer tissues. The drug has been studied as a potential treatment for breast cancer because it targets the estrogen receptor and prevents the growth of tumor cells in preclinical models. This drug is currently being investigated for its effects on tumor suppression and prevention of recurrence.

Fórmula: C₂₆H₂₉NO

Pureza: Min. 98.0 Area-%

Peso molecular: 371.51 g/mol

Ref: 3D-W-108788

Tamoxifen

CAS: 10540-29-1

Fórmula: C₂₆H₂₉NO

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 371.5146

Ref: IN-DA008R95