CAS 105454-04-4
:7-Epitaxol
Descrição:
7-Epitaxol, com o número CAS 105454-04-4, é um derivado sintético do composto natural paclitaxel, conhecido por suas propriedades anticancerígenas. Este composto é caracterizado por sua complexa estrutura policíclica, que inclui um núcleo de taxano essencial para sua atividade biológica. 7-Epitaxol exibe um mecanismo de ação semelhante ao do paclitaxel, funcionando principalmente como um estabilizador de microtúbulos, inibindo assim a divisão celular e promovendo a apoptose em células cancerosas. Sua eficácia é frequentemente avaliada em vários tipos de câncer, incluindo câncer de mama e de ovário. O composto é tipicamente administrado em uma formulação que melhora sua solubilidade e biodisponibilidade, uma vez que é pouco solúvel em água. Além disso, 7-Epitaxol pode ter diferentes propriedades farmacocinéticas em comparação com o paclitaxel, potencialmente levando a variações nos resultados terapêuticos e efeitos colaterais. Pesquisas em andamento visam entender melhor sua gama completa de atividades biológicas e aplicações potenciais na terapia do câncer.
Fórmula:C47H51NO14
InChI:InChI=1/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32+,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
Chave InChI:InChIKey=RCINICONZNJXQF-LYTKHFMESA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]
Sinónimos:- (2alpha,5beta,7alpha,10beta,13alpha)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- 7-Epipaclitaxel
- 7-epi-Paclitaxel
- 7-epi-Taxol
- Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
- Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR- (2aalpha,4alpha,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4α,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- Epitaxol
- 7-Epitaxol
- Paclitaxel EP impurity E
- 7-EpipaclitaxelQ: What is
- 7-EPIPACLITAXEL; 7-EPITAXOL; 7-EPI-PACLITAXEL; EPITAXOL
- 7-Epi Paclitaxel (Paclitaxel EP Impurity E)
- Paclitaxel Impurity 5（Paclitaxel EP Impurity E）
- Paclitaxel Impurity E (7-epi Paclitaxel)
- 7-Epipaclitaxel Q: What is the storage condition of
- 7-Epipaclitaxel, 98%, from Taxus chinensis (Pilg.) Rehder
- Propanedioicacid,2-(2-propyn-6-yl)-,diethylester
- Paclitaxel Impurity E
- Paclitaxel 7-Epi-Impurity
- 7-Epipaclitaxel(crude)
- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid derivative
- 7-Epipaclitaxel Q: What is the CAS Number of
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4α,4aβ,6β
- Paclitaxel EP Impurity E (7-epi Paclitaxel)
- EPITAXOL, 7-
- 7-epi-Paclitaxel(7-Epitaxol)
- Paclitaxel Impurity Ⅲ:(7-Epi-Paclitaxel)
- Benzenepropanoicacid,beta-(benzoylaMino)-alpha-hydroxy-,6,12B-bis(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,11-dihydroxy-4A,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-ylester,(2ar-(
- 7-Epipaclitaxel, froM Taxus chinensis
- Paclitaxel Impurity E (7-Diverse Taxol)
- inhibit,Microtubule/Tubulin,7 epi Taxol,7epiTaxol,Inhibitor
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Pureza (%)
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100
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0
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50
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90
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95
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100
10 produtos.
Paclitaxel EP Impurity E (7-epi Paclitaxel)
CAS:Fórmula:C47H51NO14Cor e Forma:Pale Pink SolidPeso molecular:853.927-Epitaxol
CAS:Fórmula:C47H51NO14Pureza:≥ 98.0%Cor e Forma:White to off-white powderPeso molecular:853.927-epi-Taxol
CAS:<p>Paclitaxel is an anticancer drug that belongs to the class of taxanes. Paclitaxel binds to cell membranes and interferes with cell division by preventing the polymerization of microtubule proteins. This drug can be prepared by high-performance liquid chromatography (HPLC) and has minimal toxicity in humans, but is highly toxic in rats. Paclitaxel also inhibits glucose uptake in breast cancer cells, leading to significant cytotoxicity. It has inhibitory properties against toll-like receptor 4, which may contribute to its anti-inflammatory effects.</p>Fórmula:C47H51NO14Pureza:Min. 95%Cor e Forma:PowderPeso molecular:853.91 g/mol
