CAS 105979-17-7

Benidipino

Descrição:

Benidipino é um bloqueador de canais de cálcio usado principalmente no tratamento da hipertensão e da angina de peito. Pertence à classe dos antagonistas do cálcio dihidropiridínicos, que funcionam inibindo a entrada de íons de cálcio através dos canais de cálcio tipo L no músculo liso vascular e no tecido cardíaco, levando à vasodilatação e à redução da carga cardíaca. Benidipino exibe um mecanismo de ação dual único, pois bloqueia tanto os canais de cálcio tipo L quanto os tipo T, aumentando sua eficácia na redução da pressão arterial. A substância é caracterizada por sua lipofilicidade, que contribui para sua capacidade de penetrar efetivamente nas membranas celulares. Geralmente é administrada por via oral e tem uma meia-vida relativamente longa, permitindo a dosagem uma vez ao dia. Efeitos colaterais comuns podem incluir tontura, dor de cabeça e edema periférico, embora geralmente seja bem tolerada. Assim como outros medicamentos de sua classe, é aconselhável ter cautela em pacientes com certas condições cardiovasculares ou aqueles que tomam outros agentes antihipertensivos. No geral, Benidipino representa uma opção valiosa no manejo de doenças cardiovasculares.

Fórmula: C₂₈H₃₂ClN₃O₆

InChI: InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1

Chave InChI: InChIKey=QZVNQOLPLYWLHQ-MKNUCDGGNA-N

SMILES: C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3[C@@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4

Sinónimos:

• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)
• (3R)-1-benzylpiperidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-
• BND
• Benidipine Hcl
• Capadipine
• Nacadipine
• (±)-Benidipine
• Benidipine
• (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester
• BENIDIPINE HYDROCHLORIDE
• (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester
• CONIEL
• (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester

Benidipine

CAS: 105979-17-7

Fórmula: C₂₈H₃₁N₃O₆

Peso molecular: 505.56

Ref: 7W-GP5445

Benidipine Hydrochloride

CAS: 105979-17-7, 91599-74-5

Fórmula: C₂₈H₃₁N₃O₆·HCl

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light yellow to Yellow to Orange powder to crystal

Peso molecular: 542.03

Ref: 3B-B5629

Benidipine

CAS: 105979-17-7

Benidipine: potent oral calcium blocker, boosts nitric oxide synthase, enhances coronary flow, protects heart cells post-ischemia.

Fórmula: C₂₈H₃₁N₃O₆

Cor e Forma: Solid

Peso molecular: 505.56

Ref: TM-T63452

Benidipine

CAS: 105979-17-7

Benidipine is a calcium channel blocker that inhibits the flow of calcium ions into cardiac and smooth muscle cells, which decreases the rate of these cells' contractions. Benidipine also has been shown to have a protective effect on the heart by preventing injury from coronary artery disease and other cardiovascular diseases. In addition, benidipine is not broken down in the liver and has a low risk of drug interactions. Benidipine has been found to be effective in reducing blood pressure in patients with chronic renal failure, although it may cause tubulointerstitial injury. The effects of benidipine are thought to be due to its ability to inhibit the release of growth factor-β1 from human polymorphonuclear leukocytes (PMNLs) and inhibit the proliferation of HL-60 cells.

Pureza: Min. 95%

Ref: 3D-FB176235

Benidipine 5-(1-Benzylpiperidin-3-yl)-d10

Produto Controlado

CAS: 105979-17-7

Fórmula: C₃₉D₁₀H₃₄N₄O₆

Cor e Forma: Neat

Peso molecular: 674.851

Ref: TR-B157507