CAS 106900-12-3

1-Piperidinbutanamida, 4-(4-clorofenil)-4-hidroxi-N,N-dimetil-α,α-difenil-, 1-óxido, trans-

Descrição:

1-Piperidinbutanamida, 4-(4-clorofenil)-4-hidroxi-N,N-dimetil-α,α-difenil-, 1-óxido, trans- (CAS 106900-12-3) é um composto químico caracterizado por sua estrutura complexa, que inclui um anel de piperidina, um grupo butanamida e múltiplos substituintes aromáticos. A presença de um grupo 4-clorofenila e um grupo hidroxila contribui para sua potencial atividade biológica e propriedades de solubilidade. A substituição dimetila no átomo de nitrogênio da amida aumenta sua lipofilicidade, o que pode influenciar sua interação com membranas biológicas. A designação de 1-óxido do composto indica a presença de um átomo de nitrogênio oxidado, o que pode afetar sua reatividade e estabilidade. Este composto pode exibir propriedades farmacológicas, tornando-o de interesse na química medicinal. Sua configuração trans sugere arranjos espaciais específicos dos substituintes, que podem ser cruciais para sua atividade biológica. No geral, as características estruturais únicas deste composto o posicionam como um candidato para mais pesquisas no desenvolvimento de medicamentos e campos relacionados.

Fórmula: C₂₉H₃₃ClN₂O₃

InChI: InChI=1/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3

Chave InChI: InChIKey=KXVSBTJVTUVNPM-UKPNQBOSNA-N

SMILES: C(CCN1(=O)CC[C@@](O)(CC1)C2=CC=C(Cl)C=C2)(C(N(C)C)=O)(C3=CC=CC=C3)C4=CC=CC=C4

Sinónimos:

• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, 1-oxide, (E)-
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
• 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
• Arestal
• Loperamide N-oxide
• Loperamide oxide [INN:BAN]
• Loperamide oxyde
• Loperamide oxyde [French]
• Loperamidum oxidum
• Loperamidum oxidum [Latin]
• Oxido de loperamida
• Oxido de loperamida [Spanish]
• R 58425
• trans-4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide 1-oxide
• trans-N-Oxide of loperamide
• Loperamide oxide
• DIPHENYLBUTANAMIDE HYDROCHLORIDE
• Loperamide EP Impurity F HCl
• LoperaMide-d6 N-Oxide
• 4-[TRANS-4-(4-CHLOROPHENYL)-4-HYDROXY-1-
• Loperamide N-oxideQ: What is
• Loperamide USP Related Compound F
• Loperamide N-oxide Q: What is the CAS Number of
• Loperamide N-oxide Q: What are the applications of
• Loperamide Impurity 6（Loperamide EP Impurity F）
• Loperamide N-oxide Q: What is the storage condition of
• Loperamide impurity-F(EP)
• Loperamide EP Impurity F
• trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide
• Loperamide Related Compound F ((1r,4s)-4-(4-Chlorophenyl)-1-[4-(dimethylamino)-4-oxo-3,3-diphenylbu (1370065)
• Loperamide EP Impurity F/ Loperamide Related Compound F (Loperamide N-Oxide)
• Loperamide oxide monohydrate CRS
• trans-Loperamide N-Oxide
• Loperamide Hydrochloride Impurity F
• OXIDOPIPERIDIN-1-YL]-N,N-DIMETHYL-2,2-
• Loperamide Hydrochloride EP Impurity F
• 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-oxide

LOPERAMIDE OXIDE MONOHYDRATE CRS

CAS: 106900-12-3

LOPERAMIDE OXIDE MONOHYDRATE CRS

Fórmula: C₂₉H₃₃ClN₂O₃

Cor e Forma: White. Powder.

Peso molecular: 493.0369

Ref: 41-Y0000341

Loperamide N-oxide

CAS: 106900-12-3

Loperamide N-oxide

Cor e Forma: Off-White

Ref: 47-636

Loperamide oxide

CAS: 106900-12-3

Loperamide oxide

Peso molecular: 493.04g/mol

Ref: 54-BUP14161

Loperamide EP Impurity F (Loperamide USP Related Compound F, trans-Loperamide N-Oxide)

CAS: 106900-12-3

Fórmula: C₂₉H₃₃ClN₂O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 493.04

Ref: 4Z-L-0910

Loperamide Oxide

Produto Controlado

CAS: 106900-12-3

Fórmula: C₂₉H₃₃ClN₂O₃

Cor e Forma: Neat

Peso molecular: 493.04

Ref: 86-MM0025.09

trans-Loperamide N-Oxide

Produto Controlado

CAS: 106900-12-3

Stability Hygroscopic
Applications Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354 (1995), Hesselink, D., et al.: Clin. Pharmacol. Ther., 74, 245 (2003), Hooijberg, J., et al.: Biochem. Pharmacol., 67, 1541 (2004),

Fórmula: C₂₉H₃₃ClN₂O₃

Cor e Forma: Off-White

Peso molecular: 493.04

Ref: TR-L469460

Loperamide N-oxide

CAS: 106900-12-3

μ-opioid receptor agonist; calcium channel inhibitor; anti-diarrheal

Fórmula: C₂₉H₃₃ClN₂O₃

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 493.04 g/mol

Ref: 3D-IL24926

Loperamide oxide

CAS: 106900-12-3

Loperamide oxide (R 58425) is a secreted antidiarrheal agent that increases peristalsis and inhibits intestinal absorption of water and ions.

Fórmula: C₂₉H₃₃ClN₂O₃

Cor e Forma: Solid

Peso molecular: 493.04

Ref: TM-T25753