CAS 107007-99-8

Cloridrato de Granisetrona

Descrição:

Cloridrato de Granisetrona é um antagonista seletivo do receptor de serotonina 5-HT3, utilizado principalmente como antiemético para prevenir náuseas e vômitos associados à quimioterapia, radioterapia e cirurgia. É um pó cristalino branco a off-white que é solúvel em água e apresenta uma faixa de pH tipicamente entre 4 e 6 quando dissolvido. A fórmula molecular de Cloridrato de Granisetrona reflete sua estrutura, que inclui um anel de piperidina, contribuindo para sua atividade farmacológica. Este composto é frequentemente administrado por via oral ou intravenosa, dependendo do cenário clínico. O granisetron atua bloqueando a ação da serotonina nos receptores 5-HT3 no trato gastrointestinal e no sistema nervoso central, inibindo assim o reflexo do vômito. Sua farmacocinética indica uma meia-vida relativamente longa, permitindo um manejo eficaz de náuseas e vômitos com menos doses. Como qualquer medicamento, os efeitos colaterais potenciais podem incluir dor de cabeça, constipação e tontura, exigindo monitoramento cuidadoso durante o tratamento.

Fórmula: C₁₈H₂₄N₄O·ClH

InChI: InChI=1/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

Chave InChI: InChIKey=QYZRTBKYBJRGJB-WQTKJZBYNA-N

SMILES: C(N[C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])(=O)C=3C=4C(N(C)N3)=CC=CC4.Cl

Sinónimos:

• 1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxamid
• 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl)-1H-Indazole-3-Carboxamide
• 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl)-1H-Indazole-3-Carboxamide Hydrochloride (1:1)
• 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide
• 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide Hydrochloride
• 1H-Indazole-3-Carboxamide, 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl)-, Monohydrochloride, Endo-
• 1H-Indazole-3-Carboxamide, 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-, Monohydrochloride
• 1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride (1:1)
• 9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv.
• Brl-43694A
• Brl-43694A, Kytril, 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide Hydrochloride
• Endo-1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxa
• Endo-Monohydrochlorid
• Endo-Monohydrochloride
• Granisertrol Hydrochloride
• Granisertronhydrochloride
• Granisetron Hcl
• Granisetron Hydrocholride
• Granisetronhclfda
• Granisetronhydrochloridefdainspected
• Granistron Hydrochloride
• Gransetron Hcl
• Kytril
• Midehydrochloride
• GranisetronBase

Granisetron Hydrochloride

CAS: 107007-99-8

Cor e Forma: Neat

Ref: 61-FOR0398.00

GRANISETRON HYDROCHLORIDE CRS

CAS: 107007-99-8

GRANISETRON HYDROCHLORIDE CRS

Fórmula: C₁₈H₂₅ClN₄O

Cor e Forma: White. Powder.

Peso molecular: 348.8703

Ref: 41-Y0000396

Granisetron Hydrochloride

CAS: 107007-99-8

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₁₈H₂₄N₄O·HCl

Cor e Forma: White Off-White Powder

Peso molecular: 348.87

Ref: 45-1298106

Granisetron hydrochloride

CAS: 107007-99-8

Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy

Fórmula: C₁₈H₂₅ClN₄O

Pureza: 99.88% - 99.93%

Cor e Forma: White To Off-White Crystalline Solid

Peso molecular: 348.87

Ref: TM-T1042

Granisetron hydrochloride

CAS: 107007-99-8

Fórmula: C₁₈H₂₄N₄O·HCl

Pureza: 98.0 - 102.0 % (dried substance)

Cor e Forma: White or almost white powder

Peso molecular: 348.87

Ref: 7W-GP3615

Granisetron hydrochloride, EP, USP grade

CAS: 107007-99-8

Fórmula: C₁₈H₂₄N₄O·HCl

Peso molecular: 348.87

Ref: 7W-GP9011

Granisetron HCl

CAS: 107007-99-8

Fórmula: C₁₈H₂₄N₄O·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 312.42 36.46

Ref: 4Z-G-073

Granisetron Hydrochloride

CAS: 107007-99-8, 109889-09-0

Fórmula: C₁₈H₂₄N₄O·HCl

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 348.88

Ref: 3B-G0401

Granisetron Hydrochloride

CAS: 107007-99-8

Cor e Forma: Neat

Ref: 86-MM0398.00

Granisetron Hydrochloride

Produto Controlado

CAS: 107007-99-8

Applications A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor
References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),

Fórmula: C₁₈H₂₄N₄O·ClH

Cor e Forma: Neat

Peso molecular: 348.87

Ref: TR-G780000

Granisetron Hydrochloride

CAS: 107007-99-8

Fórmula: C₁₈H₂₄N₄OHCl

Peso molecular: 312.4 : 36.5

Ref: ST-EA-CP-G16011

Granisetron hydrochloride

Produto Controlado

CAS: 107007-99-8

Serotonin receptor 5-HT3 antagonist

Fórmula: C₁₈H₂₅ClN₄O

Pureza: Min. 95%

Cor e Forma: Powder

Ref: 3D-FG23703