CAS 1088-11-5
:2H-1,4-benzodiazepin-2-ona, 7-cloro-1,3-diidro-5-fenil-
Descrição:
2H-1,4-benzodiazepin-2-ona, 7-cloro-1,3-diidro-5-fenil- é um composto químico pertencente à classe das benzodiazepinas, caracterizado por seus anéis fundidos de benzeno e diazepina. Este composto normalmente exibe propriedades como efeitos sedativos, ansiolíticos e relaxantes musculares, tornando-o relevante na farmacologia. A presença de um átomo de cloro na posição 7 e um grupo fenila na posição 5 contribui para sua reatividade química única e atividade biológica. É frequentemente estudado por suas potenciais aplicações terapêuticas, particularmente no tratamento da ansiedade e distúrbios do sono. A estrutura do composto permite interações com o sistema nervoso central, principalmente através da modulação dos receptores GABA, que são cruciais para a neurotransmissão inibitória. Além disso, sua solubilidade e estabilidade podem variar com base nas condições ambientais, influenciando sua biodisponibilidade e eficácia. Precauções de segurança e manuseio são essenciais devido às suas propriedades farmacológicas, e está sujeito a controles regulatórios em muitas jurisdições.
Fórmula:C15H11ClN2O
InChI:InChI=1/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
Chave InChI:InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N
SMILES:ClC=1C=C2C(=NCC(=O)NC2=CC1)C3=CC=CC=C3
Sinónimos:- 1-Demethyldiazepam
- 7-Chloro-1,3-dihydro-1H-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazapin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one
- 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- 7-Chloro-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
- 7-Chloro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
- 7-Chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
- 7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
- 7-Chloro-5-phenyl-2-oxo-1,2-dihydro-1,4-benzodiazepine
- 7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
- A 101
- Calmday
- Dealkylprazepam
- Demethyldiazepam
- Demoxazepam
- Desalkylprazepam
- Desmethyldiazepam
- Dmdz
- Madar
- N-Demethyldiazepam
- N-Deoxydemoxepam
- N-Descyclopropylmethylprazepam
- N-Desmethyldiazepam
- N1-Desmethyldiazepam
- N<sup>1</sup>-Desmethyldiazepam
- Nordaz
- Nordazepam
- Nordiazepam
- Norprazepam
- Nsc 46078
- Nsc 631619
- Praxadium
- Ro 5-2180
- Sigma D 7282
- Stilny
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
- DIAZEPAM, DESMETHYL (RO 5-2180, NORDIAZE P
- 7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
- N-Deoxydemoxapam
- 1,4-BENZODIAZEPIN-2-ONE,7-CHLORO-1,3-DIHYDRO-5-PHENYL-
- NDD
- Nordiazepam solution
- Nordazepam CIV (50 mg) (7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)
- Methanol (test Nordiazepam,1.0mg/mL)
- Ro 52180434
- Chlordesmethyldiazepam
- 7-Chloro-1,3-dihydro-5-phenyl-
- Clorazepate (break down)
- 1,3-Dihydro-7-Chloro-5-Phenyl-2H-1
- DESMETHYLDIAZEPAM METHANOL SOLUTION
- Diazepam EP impurity A
- Desmethyldiazepam solution
- 1,3-Dihydro-7-Chloro-5-Phenyl-2H-1,4-Benzodiazepine-2-One
- DESMETHYLDIAZEPAM--DEA SCHEDULE IV ITEM
- NDZ
- 7-chloro-1,3-dihydro-5-phenyl-2h-4-benzodiazepin-2-one
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Pureza (%)
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100
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50
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90
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95
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100
12 produtos.
Nordiazepam-d5 (phenyl-d5)
CAS:Produto ControladoPureza:99 atom % DCor e Forma:White SolidPeso molecular:275.757-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nordazepam)
CAS:Produto ControladoCor e Forma:NeatNordazepam
CAS:Produto Controlado<p>Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).<br>References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),<br></p>Fórmula:C15H11ClN2OCor e Forma:White To Light YellowPeso molecular:270.71Desmethyl diazepam
CAS:Produto Controlado<p>Diazepam is a long-acting benzodiazepine drug that is used for the treatment of a variety of conditions, such as anxiety, insomnia, muscle spasms, and alcohol withdrawal. Diazepam has been shown to have anti-convulsant properties. The hydroxyl group on diazepam's side chain is converted to an ester in order to make it more lipid soluble and therefore more readily absorbed by the body. This conversion occurs partially through the action of enzymes found in the liver microsomes of rats and humans. Desmethyldiazepam (DMDZ) is formed from diazepam by the enzyme monoamine oxidase (MAO). DMDZ has similar pharmacological properties to its parent compound but with a shorter duration of action.<br>Maternal blood levels of DMDZ are higher than those found in serum or plasma, which may be due to differences in protein binding between these two compartments.</p>Fórmula:C15H11ClN2OPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:270.71 g/molNordazepam (1.0 mg/mL in Methanol)
CAS:Produto ControladoFórmula:C15H11ClN2OCor e Forma:Single SolutionPeso molecular:270.71Nordazepam CIV (7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)
CAS:Produto ControladoAlprazolam(inn), camazepam (inn), chlordiazepoxide (inn), clonazepam (inn), clorazepate & other heterocyclic compounds with nitro atom(s) onlyFórmula:C15H11ClN2OCor e Forma:Light Yellow White PowderPeso molecular:270.05599
