CAS 1092939-17-7

Jakafi

Descrição:

Jakafi, conhecido genericamente como ruxolitinibe, é um inibidor seletivo das quinases Janus (JAK1 e JAK2) e é utilizado principalmente no tratamento de certas neoplasias mieloproliferativas, como a policitemia vera e a mielofibrose. Funciona modulando a resposta imunológica e reduzindo a inflamação ao inibir as vias de sinalização de várias citocinas. O ruxolitinibe é administrado por via oral e é caracterizado por sua capacidade de melhorar os sintomas relacionados a essas condições, como esplenomegalia e sintomas constitucionais. A substância possui uma fórmula molecular que reflete sua estrutura complexa, que inclui um núcleo de pirrolo[2,3-d]pirimidina. Sua farmacocinética indica uma biodisponibilidade moderada, com o metabolismo ocorrendo principalmente no fígado através das enzimas do citocromo P450. Efeitos colaterais comuns podem incluir anemia, trombocitopenia e aumento do risco de infecções devido às suas propriedades imunossupressoras. No geral, Jakafi representa um avanço significativo nas terapias direcionadas para distúrbios hematológicos.

Fórmula: C₁₇H₁₈N₆·H₃PO₄

InChI: InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

Chave InChI: InChIKey=JFMWPOCYMYGEDM-XFULWGLBSA-N

SMILES: [C@H](CC#N)(N1C=C(C2=C3C(=NC=N2)NC=C3)C=N1)C4CCCC4.P(=O)(O)(O)O

Sinónimos:

• (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile
• 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1)
• INC 424 phosphate
• INCB 018424 phosphate
• Incb-018424
• Jakafi
• Jakavi
• R-Incb018424
• R-Ruxolitinib
• Ruxolitinib (INCB 018424)
• Ruxolitinib phosphate
• Ruxolitinib phosphate salt
• INC424
• INCB018424;INCB-018424;INCB 018424
• (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
• Ruxolitinib phosphate(INCB018424)
• Beta-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(Betar)-1H-pyrazole-1-propanenitrile, phosphate
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
• INCB018424 PHOSPHATE;INCB 018424 PHOSPHATE;INCB-018424 PHOSPHATE;RUXOLITINIB
• phosphenoperoxoic acid compound with (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile and dihydrogen (1:1:1)
• (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosph
• Ruxolitinib (INCB-18424) phosphate
• Ruxolitinib Phosphate (INC-424, INCB-18424, INCB-018424, Jakafi and Jakavi)
• (R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
• INCB018424 (phosphate)
• Ruxolitinib phosphate ISO 9001：2015 REACH
• (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
• Jakafi (ruxolitinib)
• INCB 018424(Ruxolitinib Phosphate)
• RUXOLITINIB(INCB018424) PHOSPHATE
• Ruxotinib phosphate
• 10-dimethoxyptercarpan
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid
• Ruxolitinib phosphate, >=98%
• (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate

Pureza: ≥98%

Peso molecular: 404.36g/mol

Ref: 54-BUP17785

Ruxolitinib Phosphate

CAS: 1092939-17-7

Fórmula: C₁₇H₁₈N₆·H₃O₄P

Cor e Forma: White To Off-White Solid

Peso molecular: 306.37 97.99

Ref: 4Z-R-093001

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

CAS: 1092939-17-7

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Pureza: 98%

Peso molecular: 404.36g/mol

Ref: 54-OR302722

Ruxolitinib Phosphate Salt

CAS: 1092939-17-7

Ruxolitinib Phosphate Salt

Fórmula: C₁₇H₁₈N₆·H₃O₄P

Pureza: >99%

Cor e Forma: white solid

Peso molecular: 404.36g/mol

Ref: 54-BIFK0028

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.

Fórmula: C₁₇H₂₁N₆O₄P

Pureza: 98% - >99.99%

Cor e Forma: Solid

Peso molecular: 404.36

Ref: TM-T3043

Ruxolitinib . phosphate salt

CAS: 1092939-17-7

Ref: 7W-GW4048

Ruxolitinib Phosphate

Produto Controlado

CAS: 1092939-17-7

Applications The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

Fórmula: C₁₇H₁₈N₆·H₃O₄P

Cor e Forma: Off White Solid

Peso molecular: 404.36

Ref: TR-R702005

Ruxolitinib phosphate

CAS: 1092939-17-7

Pureza: 99%

Peso molecular: 404.367

Ref: 10-F979379

Ruxolitinib phosphate

Produto Controlado

CAS: 1092939-17-7

Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.

Fórmula: C₁₇H₁₈N₆•H₃O₄P

Pureza: Min. 95%

Peso molecular: 404.36 g/mol

Ref: 3D-FR167906