CAS 1093861-60-9
:Afoxolaner
Descrição:
Afoxolaner é um inseticida e acaricida pertencente à classe de compostos isoxazolinas, utilizado principalmente na medicina veterinária para o tratamento e prevenção de infestações de pulgas e carrapatos em cães e gatos. Seu mecanismo de ação envolve a inibição dos canais de cloro ativados por ácido gama-aminobutírico (GABA) e glutamato, levando à paralisia e morte dos parasitas-alvo. Afoxolaner é caracterizado por sua alta eficácia contra um amplo espectro de ectoparasitas, incluindo pulgas, carrapatos e ácaros, e é tipicamente administrado por via oral na forma de comprimidos mastigáveis. O composto é conhecido por seus efeitos duradouros, proporcionando proteção por várias semanas após a administração. Afoxolaner geralmente é bem tolerado em animais de estimação, com baixa incidência de efeitos adversos. Seu perfil de segurança, combinado com sua eficácia, o tornou uma escolha popular entre os veterinários para o manejo de infestações parasitárias. Assim como qualquer fármaco, é importante seguir as diretrizes de dosagem e consultar um veterinário para o uso apropriado.
Fórmula:C26H17ClF9N3O3
InChI:InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)
Chave InChI:InChIKey=OXDDDHGGRFRLEE-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1(CC(=NO1)C=2C3=C(C(C(NCC(NCC(F)(F)F)=O)=O)=CC2)C=CC=C3)C4=CC(C(F)(F)F)=CC(Cl)=C4
Sinónimos:- 4-[5-(3-chloro-5-trifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalene-1-carboxylic acid [(2,2,2-trifluoroethylcarbamoyl)-methyl]-amide
- 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
- 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
- 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
- Afoxolaner
- Nexgard
- Avrana
- China biggest manufacturer,Afoxolaner,1093861-60-9
- 4-(5-(3-Chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide
- afoxolaner-007
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12 produtos.
4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
CAS:Fórmula:C26H17ClF9N3O3Pureza:98%Cor e Forma:SolidPeso molecular:625.8701Afoxolaner
CAS:<p>Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.</p>Fórmula:C26H17ClF9N3O3Pureza:99.1% - 99.38%Cor e Forma:SolidPeso molecular:625.87Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Fórmula:C26H17ClF9N3O3Peso molecular:625.87Afoxolaner 100 µg/mL in Acetonitrile
CAS:Produto ControladoFórmula:C26H17ClF9N3O3Cor e Forma:Single SolutionPeso molecular:625.87Afoxolaner
CAS:Afoxolaner is a bicyclic heterocycle that belongs to the class of insecticides. It is administered orally and has a high bioavailability in rats and dogs. Afoxolaner has been shown to have a pharmacokinetic profile similar to that of the reference drug, deltamethrin, with an effective dose range from 0.1-0.5 mg/kg in rats and dogs. The terminal half-life of afoxolaner is 7 days after oral administration. Afoxolaner is also effective against fleas, ticks, lice, mites, and mosquitoes in animal models and has been shown to be safe for use in cats and dogs at doses up to 1mg/kg (1mg/kg). There are no reports of allergic reactions or cutaneous lesions related to afoxolaner treatment.Fórmula:C26H17ClF9N3O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:625.87 g/mol
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