CAS 1094-61-7

beta-nicotinamida mononucleotídeo

Descrição:

beta-nicotinamida mononucleotídeo (NMN) é um nucleotídeo derivado de ribose, nicotinamida e fosfato. Desempenha um papel crucial no metabolismo celular como precursor do dinucleotídeo de nicotinamida e adenina (NAD+), uma coenzima vital envolvida em reações redox e produção de energia dentro das células. O NMN é reconhecido por seus potenciais benefícios à saúde, particularmente na pesquisa sobre envelhecimento, pois pode ajudar a aumentar os níveis de NAD+, que tendem a diminuir com a idade. Este composto é tipicamente encontrado em pequenas quantidades em vários alimentos, incluindo vegetais e frutas. O NMN é solúvel em água, permitindo uma fácil absorção em sistemas biológicos. Sua estabilidade pode ser influenciada por fatores como pH e temperatura, que são considerações importantes no armazenamento e formulação. A pesquisa sobre NMN se expandiu, focando em suas implicações para a saúde metabólica, neuroproteção e longevidade geral. No entanto, embora promissor, mais estudos são necessários para entender completamente seus mecanismos e potencial terapêutico.

Fórmula: C₁₁H₁₅N₂O₈P

InChI: InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1

Chave InChI: InChIKey=DAYLJWODMCOQEW-TURQNECASA-N

SMILES: O[C@H]1[C@@H](O[C@H](COP(=O)([O-])O)[C@H]1O)[N+]=2C=C(C(N)=O)C=CC2

Sinónimos:

• 3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium
• 3-Carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt
• 3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium
• 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium
• NMN
• NMN (mononucleotide)
• Nicotinamide mononucleotide
• Nicotinamide ribonucleoside 5′-phosphate
• Nicotinamide ribonucleotide
• Nicotinamide ribotide
• Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt
• Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, hydroxide, inner salt
• Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, inner salt
• Pyridinium, 3-carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt
• coenzyme NMN
• β-<span class="text-smallcaps">D</span>-NMN
• β-NMN
• β-Nicotinamide mononucleotide
• Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, inner salt
• Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)-, hydroxide, inner salt
• 3-Carbamoyl-1-β-D-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt
• Pyridinium, 3-carbamoyl-1-β-D-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt
• β-Nicotinamide ononucleotide
• beta-D-NMN
• Nicotinamide nucleotide
• β-nicotinamide D-ribonucleotide
• NMN zwitterion
• β-Nicotinamide Moonucleotide
• Nicotimide mononucleotide
• 99% NMN CAS 1094 61 7
• β-Nicotinamide Mononucleotid
• Nicotinamide mononuclotide
• β-Nicotinamidse Mononucleotide
• β-D-NMN
• beta-Nicotinamide Moonucleotide
• NMN powder
• BETA-NMN POWDER

β-Nicotinamide mononucleotide

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 334.2192

Ref: IN-DA003880

β-Nicotinamide mononucleotide

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: ≥ 95.0%

Cor e Forma: White, off-white or pale yellow powder

Peso molecular: 334.22

Ref: 7W-GE9996

β-Nicotinamide Mononucleotide-13C6

CAS: 1094-61-7

Fórmula: C₅₁₃C₆H₁₅N₂O₈P

Peso molecular: 340.17

Ref: 4Z-N-133013

β-Nicotinamide mononucleotide

CAS: 1094-61-7

β-Nicotinamide mononucleotide

Pureza: ≥98%

Peso molecular: 334.22g/mol

Ref: 54-BUP15443

β-Nicotinamide Mononucleotide Sodium Salt

CAS: 1094-61-7

Fórmula: C₁₁H₁₄N₂O₈P·Na

Peso molecular: 333.21 22.99

Ref: 4Z-N-133014

Nicotinamide mononucleotide

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: 95%~99%

Peso molecular: 334.221

Ref: BP-BP4241

β-Nicotinamide Mononucleotide

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 334.22

Ref: 3B-N1123

β-Nicotinamide mononucleotide

CAS: 1094-61-7

β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). Cost effective and quality assured.

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: 99.29% - >99.99%

Cor e Forma: Solid

Peso molecular: 334.22

Ref: TM-T4721

β-Nicotinamide Mononucleotide-d4

CAS: 1094-61-7

Fórmula: C₁₁H₁₁D₄N₂O₈P

Peso molecular: 338.25

Ref: 4Z-N-133006

β-Nicotinamide Mononucleotide-13C5

CAS: 1094-61-7

Fórmula: C₆₁₃C₅H₁₅N₂O₈P

Peso molecular: 339.18

Ref: 4Z-N-133007

b-Nicotinamide mononucleotide

CAS: 1094-61-7

b-Nicotinamide mononucleotide

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: By hplc: 99.5% by area (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 334.21916g/mol

Ref: 54-BIB3016

β-Nicotinamide Mononucleotide

CAS: 1094-61-7

Stability Very Hygroscopic
Applications A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);

Fórmula: C₁₁H₁₅N₂O₈P

Cor e Forma: White

Peso molecular: 334.22

Ref: TR-N407765

β-Nicotinamide-d4 Mononucleotide (d4-major)

Produto Controlado

CAS: 1094-61-7

Fórmula: C₁₁D₄H₁₁N₂O₈P

Cor e Forma: White To Off-White

Peso molecular: 338.244

Ref: TR-N407768

b-Nicotinamide mononucleotide

CAS: 1094-61-7

b-Nicotinamide mononucleotide, or NMN, is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells that is essential for various metabolic processes. NAD+ is involved in critical functions such as DNA repair, gene expression, and cellular stress responses.

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 334.22 g/mol

Ref: 3D-NN45555

ß-Nicotinamide Mononucleotide (ß-NMN) extrapure, 98%

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: min. 98.0%

Cor e Forma: White, Crystalline powder

Peso molecular: 334.22

Ref: SR-95130

ß-Nicotinamide Mononucleotide (ß-NMN) for cell culture, 99%, Endotoxin (BET) 0.05EU/mg

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: min. 99.0%

Cor e Forma: White, Crystalline powder.

Peso molecular: 334.22

Ref: SR-63509

((2R,3S,4R,5R)-5-(3-Carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate

CAS: 1094-61-7

Fórmula: C₁₁H₁₅N₂O₈P

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 334.221

Ref: 10-F455506

β-Nicotinamide Mononucleotide-13C5

Produto Controlado

CAS: 1094-61-7

Applications The labelled analogue of a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);

Fórmula: C₅C₆H₁₅N₂O₈P

Cor e Forma: Neat

Peso molecular: 339.182

Ref: TR-N407767