CAS 109581-93-3

Hidrato de tacrolimo

Descrição:

Hidrato de tacrolimo, com o número CAS 109581-93-3, é um agente imunossupressor utilizado principalmente em transplantes de órgãos e doenças autoimunes. É derivado da bactéria Streptomyces tsukubaensis e funciona inibindo a ativação de linfócitos T, reduzindo assim a resposta imunológica. A substância aparece como um pó branco a off-white e é solúvel em solventes orgânicos como metanol e dimetilsulfóxido, mas tem solubilidade limitada em água. Hidrato de tacrolimo é frequentemente formulado como um pomada tópica ou medicamento oral, dependendo de sua aplicação. Seus efeitos farmacológicos são atribuídos à sua capacidade de se ligar à FKBP-12, uma proteína que posteriormente inibe a calcineurina, uma enzima crítica na ativação de células T. Embora eficaz, o tacrolimus pode ter efeitos colaterais, incluindo nefrotoxicidade e maior suscetibilidade a infecções, exigindo monitoramento cuidadoso durante o tratamento. No geral, Hidrato de tacrolimo é um agente terapêutico vital no manejo de condições que requerem supressão imunológica.

Fórmula: C₄₄H₆₉NO₁₂·H₂O

InChI: InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

Chave InChI: InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H].O

Sinónimos:

• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone hydrate
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, hydrate (1:1), (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• 18-Tetramethyl-8-(2-Propenyl)-,Monohydrate,(3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*
• 3-(2-(4-Hydroxy-3-Methoxycyclohexyl)-1-Methylethenyl)-14,16-Dimethoxy-9,10,12,Monohydrate
• FK-506 Monohydrate
• Tacforius
• Tacrolimus hydrate
• Tacrolimushydrate
• Tsukubaenolide hydrate

TACROLIMUS FOR SYSTEM SUITABILITY CRS

CAS: 109581-93-3

TACROLIMUS FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001933

TACROLIMUS MONOHYDRATE CRS

CAS: 109581-93-3

TACROLIMUS MONOHYDRATE CRS

Fórmula: C₄₀H₃₃N₃O₄

Cor e Forma: Added Modified

Peso molecular: 619.7077

Ref: 41-Y0001926

Tacrolimus

CAS: 109581-93-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Cor e Forma: White Powder

Peso molecular: 803.48198

Ref: 45-1642802

Tacrolimus monohydrate

CAS: 109581-93-3

Fórmula: C₄₄H₇₁NO₁₃

Pureza: 80%

Cor e Forma: Solid

Peso molecular: 822.0334

Ref: IN-DA0035MN

FK-506 monohydrate

CAS: 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: ≥ 98.0%

Cor e Forma: White to off-white solid or powder

Peso molecular: 822.03

Ref: 7W-GK6971

Tacrolimus monohydrate

CAS: 109581-93-3

Tacrolimus monohydrate

Pureza: ≥95%

Peso molecular: 822.05g/mol

Ref: 54-BUP14489

Tacrolimus Monohydrate

CAS: 109581-93-3

Tacrolimus Monohydrate

Pureza: 98%

Peso molecular: 822.03g/mol

Ref: 54-OR1025734

Tacrolimus Monohydrate

CAS: 104987-11-3, 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: >80.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 822.05

Ref: 3B-M2258

Tacrolimus monohydrate

CAS: 109581-93-3

Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.

Fórmula: C₄₄H₇₁NO₁₃

Pureza: 97.07% - 98.05%

Cor e Forma: Solid

Peso molecular: 822.05

Ref: TM-T20879

Tacrolimus RS

CAS: 109581-93-3

Cor e Forma: White

Ref: 2K-1078400021

Tacrolimus Monohydrate

CAS: 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂H₂O

Peso molecular: 804.0 : 18.0

Ref: ST-EA-CP-T39005

Tacrolimus Hydrate

CAS: 109581-93-3

Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Cor e Forma: Neat

Peso molecular: 822.03

Ref: TR-T004130

Tacrolimus monohydrate

CAS: 109581-93-3

Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerative

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 822.03 g/mol

Ref: 3D-FT33601

Tacrolimus monohydrate - Bio-X ™

CAS: 109581-93-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 822.03 g/mol

Ref: 3D-BT164433