CAS 11006-33-0

fleomicina de Streptomyces verticillus

Descrição:

A pleomicina é um antibiótico antitumoral derivado da bactéria Streptomyces verticillus. É caracterizada por sua capacidade de induzir quebras nas cadeias de DNA, o que contribui à sua eficácia no tratamento do câncer. A pleomicina é um glicopeptídeo, consistindo em uma estrutura complexa que inclui uma espinha peptídica e um componente de açúcar, o que melhora sua solubilidade e atividade biológica. O composto exibe um amplo espectro de atividade contra vários tipos de tumores, particularmente tumores de células germinativas e linfomas. Seu mecanismo de ação envolve a ligação ao DNA e a geração de radicais livres, levando a danos oxidativos. A pleomicina é tipicamente administrada por injeção e é conhecida por seus potenciais efeitos colaterais, incluindo toxicidade pulmonar e reações cutâneas. Devido às suas propriedades únicas, é frequentemente usada em combinação com outros agentes quimioterápicos para melhorar os resultados terapêuticos. O número CAS 11006-33-0 identifica exclusivamente a pleomicina em bancos de dados químicos, facilitando a pesquisa e as aplicações clínicas.

Fórmula: C₅₅H₈₆N₂₀O₂₁S₂

InChI: InChI=1/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

Sinónimos:

• 2'-{5-acetyl-15-(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)-13-[{[(2R,3S,4S,5S,6S)-3-{[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)-3-methyltetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-4',5'-dihydro-2,4'-bi-1,3-thiazole-4-carboxamide (non-preferred name)
• Phleomycin
• Phleomycin Streptomyces verticillus
• phleomycin from streptomyces*verticillus
• PHLEOMYCIN USP/EP/BP
• phleomycincomplex
• ZEOCIN(TM)
• CL990-cin
• PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
• nsc616586
• hleoMycin froM streptoMyces verticillus

Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered

CAS: 11006-33-0

Phleomycin, 20mg/mL in 5mM HEPES buffer, sterile-filtered

Ref: 02-J67027

Phleomycin

CAS: 11006-33-0

Fórmula: C₅₅H₈₅ClCuN₂₀O₂₁S₂

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 1525.5138

Ref: IN-DA00HBO1

Phleomycin

CAS: 11006-33-0

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage.

Fórmula: C₄₈H₆₉N₁₇O₂₀S₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1268.29

Ref: TM-T21498

Phleomycin, 1 pack = 1 vial

CAS: 11006-33-0

Phleomycin, 1 pack = 1 vial

Ref: 54-BI3852A

Phleomycin

CAS: 11006-33-0

Fórmula: C₅₅H₈₅O₂₁N₂₀S₂Cu·HCl

Pureza: ≥ 90% (HPLC)

Cor e Forma: Blue, hygroscopic powder

Peso molecular: 1525

Ref: 7W-GA6020

Phleomycin

CAS: 11006-33-0

Phleomycin

Cor e Forma: Powder

Peso molecular: 1,425.51g/mol

Ref: 54-BI3852

Phleomycin (PLM) ex. Streptomyces verticillus for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 11006-33-0

Fórmula: C₅₁H₇₅N₁₇O₂₁S₂

Pureza: 80-120%

Cor e Forma: Blue, Powder

Peso molecular: 1326.37

Ref: SR-62374

Phleomycin HCl

CAS: 11006-33-0

Phleomycin HCl is an antibiotic compound derived from *Streptomyces verticillus*, which is known for its robust DNA-cleaving activity. As an antibiotic, it functions primarily by inducing breaks in DNA strands, thereby inhibiting DNA replication and transcription processes. This mechanism of action is particularly effective in targeting rapidly dividing cells, making Phleomycin a valuable tool in molecular biology.

Fórmula: C₅₅H₈₅O₂₁N₂₀S₂Cu•HCl

Cor e Forma: Blue Powder

Peso molecular: 1,525 g/mol

Ref: 3D-AP156948

Phleomycin

CAS: 11006-33-0

Phleomycin is an antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing breaks by generating free radicals in the presence of oxygen and ferrous ions, leading to cell death. Phleomycin is prominently used in molecular biology applications as a selective agent in the generation of stable transfectants. It is particularly effective in selecting for cells that have integrated vectors conferring resistance, such as the Sh ble gene used in yeast, plant, and mammalian cell systems. Due to its potent DNA-cleaving ability, Phleomycin is valuable in studies requiring stringent selection pressure. Researchers commonly utilize it in experiments focusing on genetic modification and cellular resistance development.

Fórmula: C₅₁H₇₅N₁₇O₂₁S₂

Pureza: Min. 95%

Peso molecular: 1,326.38 g/mol

Ref: 3D-AP106412