CAS 11024-24-1

Digitonina

Descrição:

Digitonina é um glicosídeo derivado da planta Digitalis purpurea, comumente conhecida como dedaleira. É utilizado principalmente em bioquímica e farmacologia por sua capacidade de solubilizar seletivamente proteínas de membrana, tornando-o valioso no estudo de membranas celulares e seus componentes. Digitonina possui uma estrutura complexa, apresentando uma espinha dorsal esteroide ligada a um grupo de açúcar, o que contribui para sua natureza anfipática. Essa propriedade permite que interaja com bicamadas lipídicas, facilitando a extração de proteínas de membrana enquanto mantém sua integridade funcional. Além de suas aplicações bioquímicas, Digitonina exibe efeitos citotóxicos em certos tipos de células, o que tem implicações para seu uso em pesquisa e contextos terapêuticos potenciais. É importante manusear Digitonina com cuidado, pois pode ser tóxico em concentrações mais altas. No geral, Digitonina serve como uma ferramenta crucial no estudo da biologia de membranas e na isolação de proteínas associadas a membranas.

Fórmula: C₅₆H₉₂O₂₉

InChI: InChI=1S/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19-,20+,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32-,33+,34-,35+,36-,37+,38+,39-,40-,41-,42-,43-,44+,45-,46+,47+,48-,49+,50-,51+,52+,53+,54-,55+,56-/m1/s1

Chave InChI: InChIKey=UVYVLBIGDKGWPX-KUAJCENISA-N

SMILES: C[C@@]12[C@@]3([C@]([C@@H](O)[C@]1([C@]4([C@](CC2)([C@]5(C)[C@@](CC4)(C[C@@H](O[C@@H]6O[C@H](CO)[C@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@@H](CO)O8)[C@@H](O[C@H]%10[C@H](O)[C@@H](O)[C@H](O)CO%10)[C@H](O)[C@@H](CO)O7)[C@H](O)[C@H]6O)[C@H](O)C5)[H])[H])[H])[H])(O[C@@]%11([C@H]3C)CC[C@@H](C)CO%11)[H])[H]

Sinónimos:

• (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-(4xi)-beta-D-xylo-hexopyranosyl-(1->4)-beta-D-galactopyranoside
• (2alpha,3beta,5alpha,15beta,25R)-spirostan-2,3,15-triol
• (2α,3β,5α,15β,25R)-2,15-Dihydroxyspirostan-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-xylopyranosyl-(1→3)]-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-β-<smallcap>D</span>-galactopyranoside
• Ai3-44893
• Brn 0078654
• Digitin
• Digitogenin, 3-[O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-xylopyranosyl-(1→3)]-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-β-<smallcap>D</span>-galactopyranoside]
• Digitogenin, 3-[O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside]
• Digitogenin, glycoside
• Digitonina
• Digitonine
• Nsc 23471
• Nsc 237417
• Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• Spirostan, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)-
• beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1.fwdarw.3)-O-beta-D-galactopyranosyl-(1.fwdarw.2)-O-(beta-D-xylopyranosyl-(1.fwdarw.3))-O-beta-D-glucopyranosyl-(1.fwdarw.4)-
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-xylopyranosyl-(1→3)]-O-β-<smallcap>D</span>-glucopyranosyl-(1→4)-
• β-D-Galactopyranoside, (2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-
• Digitonin
• Spirostan, β-D-galactopyranoside deriv.

Digitonin

CAS: 11024-24-1

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: White to Light yellow powder to crystaline

Peso molecular: 1,229.32

Ref: 3B-D0540

Digitonin

CAS: 11024-24-1

Digitonin

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: white to yellowish powder

Peso molecular: 1,229.31g/mol

Ref: 54-BID3301

Digitonin

CAS: 11024-24-1

Fórmula: C₅₆H₉₂O₂₉

Pureza: 95%~99%

Peso molecular: 1229.32

Ref: BP-BP0488

Digitonin

CAS: 11024-24-1

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: White to pale yellow crystalline powder

Peso molecular: 1229.31

Ref: 7W-GC7189

Digitonin

CAS: 11024-24-1

Digitonin is a natural product of the glycoside family and is a detergent.

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: Physical Description Crystals Or White Powder (Ntp 1992)

Peso molecular: 1229.31

Ref: TM-T2721

Digitonin Glycosides

Produto Controlado

CAS: 11024-24-1

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: White Solid

Peso molecular: 1229.31

Ref: TR-D446305

Digitonin, water-soluble

CAS: 11024-24-1

Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Reaction of naturally occurring steroids carrying a 3b-hydroxyl group with digitonin results in an insoluble precipitate. Digitonin has hemolytic activity and is toxic to humans. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated beta-hydroxysterols. Digitonin is frequently used for solubilization of membrane proteins and permeabilization of cellular and nuclear membranes. Due to the complexing interactions it can be used for the determination of cholesterol and ergosterol.

Fórmula: C₅₆H₉₂O₂₉

Peso molecular: 1,229.34 g/mol

Ref: 3D-D-3200

Digitonin, stable clear, water-soluble

CAS: 11024-24-1

This Digitonin product (stable clear, water soluble) is a superior water soluble Digitonin with improved stability for aqueous solutions. Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Digitonin has hemolytic activity and is toxic to humans. Digitonin is frequently used for the solubilization of membrane proteins and for the permeabilization of cellular and nuclear membranes. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated β-hydroxysterols. This mechanism is used in procedures for the determination of cholesterol and ergosterol using Digitonin.
About this product: Aqueous solutions of conventional Digitonin will precipitate upon cooling to 4°C and will lose most of the biochemical function. Therefore, the precipitate is usually removed by filtration in many protocols. This filtration however decreases the concentration of Digitonin and alters the solubilizing power of the original product. In addition, precipitation and subsequent filtration result in an unknown Digitonin concentration in the final solutions and may negatively affect the reproducibility of any experiment with such solutions. In contrast to conventional Digitonin, our product Digitonin, stable clear, water soluble is a special grade that will not precipitate for at least one week.

Fórmula: C₅₆H₉₂O₂₉

Peso molecular: 1,229.34 g/mol

Ref: 3D-D-3203

Digitonin, water-insoluble

CAS: 11024-24-1

Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Reaction of naturally occurring steroids carrying a 3b-hydroxyl group with digitonin results in an insoluble precipitate. Digitonin has hemolytic activity and is toxic to humans. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated &beta;-hydroxysterols. Digitonin is frequently used for solubilization of membrane proteins and permeabilization of cellular and nuclear membranes. Due to the complexing interactions it can be used for the determination of cholesterol and ergosterol.

Fórmula: C₅₆H₉₂O₂₉

Peso molecular: 1,229.34 g/mol

Ref: 3D-D-3100

Digitonin - water-insoluble

CAS: 11024-24-1

Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Reaction of naturally occurring steroids carrying a 3b-hydroxyl group with digitonin results in an insoluble precipitate. Digitonin has hemolytic activity and is toxic to humans. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated β-hydroxysterols. Digitonin is frequently used for solubilization of membrane proteins and permeabilization of cellular and nuclear membranes. Due to the complexing interactions it can be used for the determination of cholesterol and ergosterol This Digitonin product is insoluble in water.

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: Powder

Peso molecular: 1,229.34 g/mol

Ref: 3D-OD09275

Digitonin (Digitin) extrapure, 50%

CAS: 11024-24-1

Fórmula: C₅₆H₉₂O₂₉

Cor e Forma: White, Crystalline powder, Clear, Colourless

Peso molecular: 1229.30

Ref: SR-53755