CAS 110417-88-4

dolastatina 10

Descrição:

dolastatina 10 é um potente peptídeo derivado do molusco marinho Dolabella auricularia, conhecido por suas significativas propriedades antitumorais. É caracterizado por uma estrutura complexa que inclui uma estrutura cíclica e uma sequência única de aminoácidos, o que contribui para sua atividade biológica. dolastatina 10 exibe fortes efeitos citotóxicos contra várias linhagens celulares cancerosas, tornando-se um assunto de interesse na pesquisa do câncer e no desenvolvimento de medicamentos. Seu mecanismo de ação envolve principalmente a interrupção da dinâmica dos microtúbulos, levando à parada do ciclo celular e à apoptose em células malignas. O composto também é notado por sua baixa toxicidade em células normais, o que aumenta seu potencial terapêutico. No entanto, sua aplicação clínica tem sido limitada devido a desafios na síntese e estabilidade. Estudos em andamento visam explorar seus derivados e análogos para melhorar a eficácia e reduzir os efeitos colaterais. No geral, dolastatina 10 representa um composto promissor na busca por novos agentes anticancerígenos.

Fórmula: C₄₂H₆₈N₆O₆S

InChI: InChI=1/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51)/t28-,29+,31-,32?,33?,35-,36-,37-,38+/m1/s1

Chave InChI: InChIKey=OFDNQWIFNXBECV-VFSYNPLYSA-N

SMILES: [C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C2=NC=CS2)=O)C)(OC)[C@]3(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@H](C(C)C)N(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC3)[H]

Sinónimos:

• <span class="text-smallcaps">L</smallcap>-Valinamide, N,N-dimethyl-<smallcap>L</span>-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
• <span class="text-smallcaps">L</smallcap>-Valinamide, N,N-dimethyl-<smallcap>L</span>-valyl-N-[2-methoxy-4-[2-[1-methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-
• Ccris 7310
• Dls 10
• Dolostatin
• L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-
• N,N-Dimethyl-<span class="text-smallcaps">L</smallcap>-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-<smallcap>L</span>-valinamide
• N,N-dimethyl-D-valyl-N-[(4R,5R)-3-methoxy-1-{2-[(1S,2S)-1-methoxy-2-methyl-3-oxo-3-{[(1R)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-D-valinamide
• N,N-dimethylvalyl-N-{3-methoxy-1-[2-(1-methoxy-2-methyl-3-oxo-3-{[2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl)pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl}-N-methylvalinamide
• Nsc 376128
• N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
• Dolastatin-10
• L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
• Dolastatin 10
• Dolastain10
• Dolastatin 10,DLS 10,NSC 376128, >99%
• From dolabella auricularia (sea hare)
• CS-1367
• Nsc376128
• B720389K560
• 6-[bis[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]
• Dolastatin 10 (NSC-376128)
• (2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
• amino]-6-oxohexanoic acid

Dolastatin 10

CAS: 110417-88-4

Fórmula: C₄₂H₆₈N₆O₆S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 785.0909

Ref: IN-DA003PVY

Dolastatin 10

CAS: 110417-88-4

Dolastatin 10

Pureza: ≥98%

Peso molecular: 785.09g/mol

Ref: 54-BUP00284

Dolastatin 10

CAS: 110417-88-4

Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

Fórmula: C₄₂H₆₈N₆O₆S

Pureza: 99.00%

Cor e Forma: Solid

Peso molecular: 785.09

Ref: TM-TP1180

Dolastatin 10

CAS: 110417-88-4

Pureza: ≥98%

Peso molecular: 785.0999756

Ref: 10-F862797