CAS 11050-94-5

oligomicina B

Descrição:

oligomicina B é um antibiótico macrolídeo que é conhecido principalmente por seu papel como inibidor da ATP sintase, uma enzima essencial no processo de fosforilação oxidativa nas mitocôndrias. É produzido pela fermentação de certas espécies de Streptomyces. oligomicina B exibe uma estrutura complexa caracterizada por um grande anel de lactona e múltiplos grupos hidroxila, contribuindo para sua atividade biológica. Este composto é particularmente notável por sua capacidade de inibir a translocação de prótons através da membrana mitocondrial, bloqueando efetivamente a produção de ATP e levando ao esgotamento de energia celular. Além de suas propriedades antibióticas, oligomicina B tem sido utilizado em pesquisas para estudar a função mitocondrial e o metabolismo energético. É importante manusear este composto com cuidado, pois pode ter efeitos significativos na respiração celular e no metabolismo. oligomicina B é tipicamente usado em ambientes de laboratório, e suas aplicações se estendem a estudos farmacológicos e investigações sobre doenças mitocondriais.

Fórmula: C₄₅H₇₂O₁₂

InChI: InChI=1/C45H72O12/c1-12-33-17-15-13-14-16-25(3)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)24(2)18-21-37(48)55-41-28(6)34(20-19-33)56-45(32(41)10)36(47)22-26(4)35(57-45)23-27(5)46/h13-15,17-18,21,24-35,38,40-42,46,49,51-52,54H,12,16,19-20,22-23H2,1-11H3/b14-13-,17-15+,21-18+/t24-,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35-,38+,40+,41+,42-,44+,45+/m1/s1

Chave InChI: InChIKey=QPRQJOHKNJIMGN-WVUAJZTGSA-N

SMILES: C[C@@H]1[C@@]2(O[C@@]3([C@@H](C)[C@]1(OC(=O)/C=C/[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@](C)(O)[C@@H](O)[C@H](C)C\C=C\C=C\[C@H](CC)CC3)[H])[H])O[C@@H](C[C@@H](C)O)[C@@H](C)CC2=O

Sinónimos:

• (1R,2′S,4E,5′S,6S,6′S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-5′,6′-dihydro-7,11,14,15-tetrahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,3′,9,13(4′H)-tetrone
• (1S,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,22S,25R,27R,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-5',6'-dihydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,3',9,13(4'H)-tetrone
• 22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-5',6'-dihydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,3',9,13(4'H)-tetrone
• Brn 5705502
• Oligomycin A, 28-oxo-
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,3′,9,13(4′H)-tetrone, 22-ethyl-5′,6′-dihydro-7,11,14,15-tetrahydroxy-6′-(2-hydroxypropyl)-5′,6,8,10,12,14,16,28,29-nonamethyl-, [1R-[1R*,4E,5′S*,6S*,6′S*(R*),7R*,8S*,10R*,11R*,12S*,14R*,15S*,16R*,18E,20E,22R*,25S*,27S*,28S*,29R*]]-
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,3′,9,13(4′H)-tetrone, 22-ethyl-5′,6′-dihydro-7,11,14,15-tetrahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-, (1R,2′S,4E,5′S,6S,6′S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-
• Oligomycin B
• OligoMycin B froM StreptoMyces
• Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone, 22-ethyl-5',6'-dihydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-
• 28-Oxooligomycin A
• OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES
• Oligomycin B fromStreptomyces diastatochromogenes

Oligomycin B

CAS: 11050-94-5

Fórmula: C₄₅H₇₂O₁₂

Pureza: 78.65%

Cor e Forma: White. Solid

Peso molecular: 805.0

Ref: 8R-CL0099

Oligomycin B from Streptomyces diastatochromogenes

CAS: 11050-94-5

Oligomycin B from Streptomyces diastatochromogenes

Fórmula: C₄₅H₇₂O₁₂

Pureza: By hplc: 99.62% (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 805.05g/mol

Ref: 54-BIO1004

Oligomycin B

CAS: 11050-94-5

Fórmula: C₄₅H₇₂O₁₂

Peso molecular: 805.1

Ref: 7W-GA9690

Oligomycin B

CAS: 11050-94-5

Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.

Fórmula: C₄₅H₇₂O₁₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 805.05

Ref: TM-T12298

Oligomycin B

CAS: 11050-94-5

Oligomycin B is an antibiotic compound, which is derived from Streptomyces species. It is an inhibitor of the mitochondrial ATP synthase complex, specifically targeting the F₀ subunit of ATP synthase. This action obstructs the proton channel, preventing the flow of protons across the mitochondrial membrane. As a result, Oligomycin B effectively halts ATP synthesis by oxidative phosphorylation, which is crucial for the survival of aerobic organisms.

Fórmula: C₄₅H₇₂O₁₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 805.05 g/mol

Ref: 3D-AO65695