CAS 11056-06-7

Bleomicina

Descrição:

Bleomicina é um antibiótico glicopeptídico que é usado principalmente na quimioterapia do câncer. É derivado da bactéria Streptomyces verticillus e é conhecido por sua capacidade de induzir quebras nas cadeias de DNA, o que leva à inibição do crescimento das células cancerosas. O composto exibe um mecanismo de ação único ao se ligar ao DNA e gerar radicais livres na presença de oxigênio, resultando em danos oxidativos. Bleomicina é particularmente eficaz contra certos tipos de tumores, incluindo câncer testicular e linfoma de Hodgkin. É administrado por injeção e pode causar efeitos colaterais como toxicidade pulmonar, reações cutâneas e febre. A substância é caracterizada por seu peso molecular relativamente baixo e uma estrutura complexa que inclui um local de ligação a metais, que é crucial para sua atividade. Devido à sua ação específica sobre células que se dividem rapidamente, Bleomicina é frequentemente usado em combinação com outros agentes quimioterápicos para aumentar a eficácia do tratamento enquanto minimiza a resistência. Seu uso requer monitoramento cuidadoso devido aos potenciais efeitos adversos, particularmente sobre a função pulmonar.

Fórmula: Unspecified

InChI: InChI=1/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1

Sinónimos:

• Blenamax
• Bleo
• Bleo-Kyowa
• Bleocin
• Bleomycins
• Nsc 125066
• [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-(4-guanidinobutylcarbamoyl)thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(3H-imidazol-4-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate
• (3-{[(2'-{(5S,8S,9S,10R,13S)-15-{6-amino-2-[(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl]-5-methylpyrimidin-4-yl}-13-[(R)-{[3-{[4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-5-[(1R)-1-hydroxyethyl]-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-2,4'-bi-1,3-thiazol-4-yl)carbonyl]amino}propyl)(dimethyl)sulfonium (non-preferred name)
• N1-(3-(dimethylsulfonio)propyl)bleomycinamide) (Bleomycin A2)
• BLM
• Blenoxane
• (2R,3S,4S,5R,6R)-2-({(3S,4S,5S,6S)-2-[2-{[(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)carbonyl]amino}-3-[(4-{[1-({2-[4-({4-[(diaminomethylidene)amino]butyl}carbamoyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}carbamoyl)-2-hydroxypropyl]amino}-2-hydroxy-1,3-dimethyl-4-oxobutyl)amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-6-ethyl-4,5-dimethyltetrahydro-2H-pyran-3-yl}oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate
• 3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino]-3-hydroxy-2-methyl-pentanoyl]amino]-3-hydroxy-butanoyl]amino]ethyl]thiazol-4-yl]thiazole-4-carbonyl]amino]propyl-dimethyl-sulfonium
• Bleomycin

Bleomycin Sulfate (mixture)

CAS: 11056-06-7, 9041-93-4

Pureza: >85.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Ref: 3B-B3972

Bleomycin

CAS: 11056-06-7

Bleomycin is an antineoplastic antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing strand breaks through the generation of free radicals, particularly in regions rich in guanine and cytosine. This leads to inhibition of DNA synthesis and, consequently, cellular replication, making it effective in targeting rapidly dividing cancer cells.

Fórmula: C₅₅H₈₄N₁₇O₂₁S₃

Pureza: Min. 95%

Peso molecular: 1,415.56 g/mol

Ref: 3D-AB30158

Bleomycin Free Base

CAS: 11056-06-7

Bleomycin Free Base, a glycopeptide antibiotic, halts DNA function and treats solid tumors.

Fórmula: C₅₅H₈₄N₁₇O₂₁S₃

Cor e Forma: Solid

Peso molecular: 1415.55

Ref: TM-T71445