CAS 112924-45-5

1,1-Dimetilheptil-11-hidroxitetrahidrocanabinol

Descrição:

1,1-Dimetilheptil-11-hidroxitetrahidrocanabinol, comumente referido como um canabinoide sintético, é um composto que imita os efeitos dos canabinoides naturais encontrados na planta de cannabis. Esta substância é caracterizada por sua complexa estrutura molecular, que inclui uma espinha dorsal de tetrahidrocanabinol (THC) modificada com uma cadeia lateral de dimetilheptila e um grupo hidroxila na posição 11. Sua fórmula química contribui para sua lipofilicidade, permitindo que interaja efetivamente com os receptores canabinoides no corpo, particularmente os receptores CB1 e CB2, que estão envolvidos em vários processos fisiológicos, como a sensação de dor, a regulação do humor e o controle do apetite. O composto é tipicamente estudado por seus potenciais efeitos terapêuticos, incluindo propriedades analgésicas e anti-inflamatórias, mas também pode apresentar efeitos psicoativos semelhantes aos do THC. Devido à sua natureza sintética, pode apresentar perfis farmacocinéticos e farmacodinâmicos diferentes em comparação com os canabinoides naturais, levantando preocupações sobre segurança, legalidade e potencial de abuso.

Fórmula: C₂₅H₃₈O₃

InChI: InChI=1/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m0/s1

Chave InChI: InChIKey=SSQJFGMEZBFMNV-PMACEKPBSA-N

SMILES: OC1=C2[C@@]3([C@@](C(C)(C)OC2=CC(C(CCCCCC)(C)C)=C1)(CC=C(CO)C3)[H])[H]

Sinónimos:

• (+)-Hu-210
• (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
• (6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
• 6H-Dibenzo[b,d]pyran-9-methanol, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-, (6aS,10aS)-
• 6H-Dibenzo[b,d]pyran-9-methanol, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-, (6aS-trans)-
• Dexanabinol
• Hu 211
• Prs 211007-000
• Sinnabidiol
• 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
• [6aS,(+)]-6a,7,10,10aβ-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol
• (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,77,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
• (6AR)-TRANS-3-(1,1-DIMETHYLHEPTYL)-6A,7,10,10A-TETRAHYDRO-1-HYDROXY-6,6-DIMETHYL-6H-DIBENZO[B,D]PYRAN-9-METHANOL
• (6AR,10AR)-3-(1,1'-DIMETHYLHEPTYL)-6A,7,10,10A-TETRAHYDRO-1-HYDROXY-6,6-DIMETHYL-6H-DIBENZO[B,D]PYRAN-9-METHANOL
• (6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
• (6aS,10aS)-3-(1,1-dimethylheptyl)-6,6-dimethyl-9-methylol-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
• (6aS)-6aα,7,10,10aβ-Tetrahydro-6,6-dimethyl-1-hydroxy-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol

HU 211-d6

Produto Controlado

CAS: 112924-45-5

Fórmula: C₂₅D₆H₃₂O₃

Cor e Forma: Neat

Peso molecular: 392.604

Ref: TR-H673507

HU 211

Produto Controlado

CAS: 112924-45-5

Applications HU-211 is a synthetic cannabinoid derivative that inhibits TNFα and interleukin-6 (1,2,3). HU-211 exhibits neuroprotective, antioxidant, and anti-inflammatory properties. It might be a useful agent for the treatment of stroke patients, by protecting neuronal lysosomes from nitric oxide (NO)-mediated toxicity.
References (1) Shohami, E., et al.: J. Neuroimmunol., 72, 169 (1997)(2) Ramazan, D., et al.: Neuochemical Res., 33, 1683 (2008) (3) Leker, R., et al.: J. Neurol. Sci., 162, 114 (1999)

Fórmula: C₂₅H₃₈O₃

Cor e Forma: Neat

Peso molecular: 386.57

Ref: TR-H673505

HU 211

Produto Controlado

CAS: 112924-45-5

HU 211 is a novel synthetic cannabinoid that has been shown to have a number of pharmacological activities. It has been shown to induce neuronal death by causing mitochondrial membrane potential depolarization, which leads to the release of cytochrome c and other apoptotic factors from the mitochondria. HU 211 has also been shown to inhibit tumor growth in animal models when administered alone or in combination with cytotoxic agents like paclitaxel. The synergistic effect between HU 211 and paclitaxel is due to their ability to decrease the expression of anti-apoptotic molecules. HU 211 also inhibits transcriptional regulation, leading to inhibition of protein synthesis and cell proliferation. HU 211's antitumor activity has been demonstrated in animal models for breast, colon, lung, liver, and prostate cancers as well as bowel disease (including colitis), Parkinson's disease, and dopamine-related disorders.

Fórmula: C₂₅H₃₈O₃

Pureza: Min. 95%

Peso molecular: 386.57 g/mol

Ref: 3D-MEA92445