CAS 114899-77-3

Trabectedina

Descrição:

Trabectedina, também conhecido pelo seu código de desenvolvimento ET-743, é um alcaloide sintético derivado da tunicada marinha Ecteinascidia turbinata. É utilizado principalmente como agente antineoplásico na terapia do câncer, particularmente para sarcomas de tecidos moles e câncer de ovário. Trabectedina funciona ligando-se ao DNA e interrompendo o processo de transcrição, levando à parada do ciclo celular e apoptose nas células cancerosas. Seu mecanismo de ação envolve a formação de adutos de DNA, que interferem na função normal da maquinaria celular. O composto exibe uma estrutura única caracterizada por um núcleo policíclico complexo e uma cadeia lateral funcionalizada, contribuindo para sua atividade biológica. Trabectedina é administrado por via intravenosa e possui um perfil farmacocinético específico, incluindo uma meia-vida relativamente curta e extensa ligação a proteínas. Os efeitos colaterais podem incluir mielossupressão, elevação de enzimas hepáticas e distúrbios gastrointestinais. Devido à sua origem e mecanismo únicos, Trabectedina representa um avanço significativo nas terapias direcionadas ao câncer, destacando o potencial de compostos derivados do mar na química medicinal.

Fórmula: C₃₉H₄₃N₃O₁₁S

InChI: InChI=1/C40H45N3O11S/c1-17-11-21-12-23-38(47)43-24-15-51-39(48)40(22-14-26(49-5)25(45)13-20(22)7-9-41-40)8-10-55-37(31(43)30(42(23)4)27(21)32(46)33(17)50-6)29-28(24)36-35(52-16-53-36)18(2)34(29)54-19(3)44/h11,13-14,23-24,30-31,37-38,41,45-47H,7-10,12,15-16H2,1-6H3/t23-,24-,30+,31+,37+,38-,40+/m0/s1

Chave InChI: InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N

SMILES: O[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C=6C(=CC(O)=C(OC)C6)CCN5)[H])=C7C(=C(C)C4OC(C)=O)OCO7)[H])([C@]8(C=9C(C[C@@]1(N8C)[H])=CC(C)=C(OC)C9O)[H])[H]

Sinónimos:

• (1'R,6R,6aR,7R,13S,14S,16R)-6',8,14-Trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydrospiro(6,16-(epithiopropanooxymethano)-7,13-imino-6aH-1,3-dioxolo(7,8)isoquino(3,2-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-5-yl acetate
• (1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one
• 1,3-Benzodioxole-5-propanoic acid,7-methyl-6-(phenylmethoxy)-α-[[(phenylmethoxy)carbonyl]amino]-,2,2-dimethoxyethyl ester
• Ccris 8133
• Ect 743
• Ecteinascidin
• Ecteinascidine 743
• Et-743
• Nsc 648766
• Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 3',4',6,6a,7,13,14,16-octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))-
• Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16R)-
• Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, 5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)-
• Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, 5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-, [6R-(6α,6aβ,7β,13β,14β,16α,20R*)]-
• Trabectedin
• Unii-Id0Yzq2Tcp
• Yondelis
• ecteinascidin 743
• ecteinascidin 743,Trabectedin,ET 743
• Trabectedin Q: What is the storage condition of
• PKVRCIRHQMSYJX-ZKZLGIKISA-N
• (1'R,6R,6aR,7R,13S,14S,16R)-
• Trabectedin Q: What is the CAS Number of
• ASMF Filed
• NSC-684766
• ECTEINASCIDIN 743; ET-743; ECTEINASCIDIN
• Trabectedin (Ecteinascidin 743)
• Trabectedin Q: What are the applications of
• Trabectedin (Yondelis)
• Yondelis R ,Trabectedin
• TrabectedinQ: What is
• Trabectedin(Ecteinascidin 743,NSC-684766,ET-743)
• Trabectedin, >95%
• Trabectedin(Ecteinascidin 743,NSC-684766,ET-743, Yondelis)
• cteinascidin

ecteinascidin 743

CAS: 114899-77-3

Fórmula: C₃₉H₄₃N₃O₁₁S

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 761.8372

Ref: IN-DA008TKA

Trabectedin

CAS: 114899-77-3

Trabectedin

Pureza: ≥98%

Peso molecular: 761.84g/mol

Ref: 54-BUP12778

Trabectedin

CAS: 114899-77-3

Fórmula: C₃₉H₄₃N₃O₁₁S

Peso molecular: 761.84

Ref: 4Z-T-298001

Trabectedin

CAS: 114899-77-3

Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research.

Fórmula: C₃₉H₄₃N₃O₁₁S

Pureza: ≥98%

Cor e Forma: Solid

Peso molecular: 761.84

Ref: TM-T17155

Trabectedin

Produto Controlado

CAS: 114899-77-3

Applications A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Antineoplastic.
References Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456 (1992), Aune, G., et al.: Anticancer Drugs, 13, 545 (2002), Herrero, A., et al.: Cancer Res., 66, 8155 (2006), Sugasawa, K., et al.: Carcinogenesis, 29, 455 (2008),

Fórmula: C₃₉H₄₃N₃O₁₁S

Cor e Forma: Neat

Peso molecular: 761.84

Ref: TR-T703500

Trabectedin

CAS: 114899-77-3

Trabectedin is a model system for investigating the role of protein genes in cancer. It is used for high throughput screening of potential biomarkers, such as blood sampling and mouse tumor models. Trabectedin has been shown to be a potent inhibitor of the p-gp substrate and has been used in vivo to treat cancers, including solid tumors and experimental models. This drug was also found to inhibit the antitumor response in normal human cells. Trabectedin is a taxane derivative that binds to the surface of cells with high affinity and prevents phosphorylation of proteins on the cell surface, which leads to inhibition of cell proliferation.

Fórmula: C₃₉H₄₃N₃O₁₁S

Pureza: Min. 95%

Cor e Forma: White/Off-White Solid

Peso molecular: 761.84 g/mol

Ref: 3D-FT28354