CAS 114977-28-5

Taxotere

Descrição:

Taxotere, com o número CAS 114977-28-5, é um agente quimioterápico utilizado principalmente no tratamento de vários tipos de câncer, incluindo câncer de mama, pulmão e próstata. Seu ingrediente ativo é o docetaxel, que é um derivado semissintético do paclitaxel. Taxotere atua como um inibidor de microtúbulos, interrompendo a função normal do fuso mitótico durante a divisão celular, inibindo assim a proliferação de células cancerosas. A substância é tipicamente administrada por via intravenosa e é conhecida por sua eficácia em combinação com outros agentes quimioterápicos. Taxotere é caracterizada por sua solubilidade em solventes orgânicos e sua formulação geralmente inclui polisorbato 80 para melhorar a solubilidade em soluções aquosas. Efeitos colaterais comuns associados ao Taxotere incluem neutropenia, fadiga, náuseas e alopecia, entre outros. Devido aos seus efeitos potentes, é classificado como um agente antineoplásico e está sujeito a monitoramento cuidadoso durante o tratamento para gerenciar possíveis reações adversas.

Fórmula: C₄₃H₅₃NO₁₄

InChI: InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41-,42-,43+/m0/s1

Chave InChI: InChIKey=ZDZOTLJHXYCWBA-VCVYQWHSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinónimos:

• (1beta,2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Ati 1123
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bind-014
• Ckd 810
• Crlx 301
• Decetaxel anhydrous
• Docefrez
• Docetaxel
• Docetaxel Anhydrous
• Docetaxol
• Docetere
• Duopafei
• Miradocetaxel
• N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
• N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
• Rp 56976
• Sid 530
• Taxotel
• docetaxcel，DTX
• )benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph
• TAXOTERE
• DOCETAXEL (TAXOTERE)
• Docetaxel9.5%
• Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih
• Docetaxel99.5%
• DOCETAXEL TRIHYDRATE
• DocetaxelAnhydrous/Trihydrate
• beta-s*),11-alpha,12-alpha,12a-alpha,12b-alpha))-a-r
• n-debenzoyl-n-(tert-butoxycarbonyl)taxol
• o-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4
• rp56976
• DocetaxelAnhydrousin-HouseStandard
• benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy
• DOCETAXEL ANHYDROUS 99.5%
• -,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr

Docetaxel

CAS: 114977-28-5

Fórmula: C₄₃H₅₃NO₁₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 807.89

Ref: 3B-D4102

Docetaxel, 99%

CAS: 114977-28-5

Docetaxel, 114977-28-5, is a taxoid antineoplastic agent and a second-generation cytotoxic antimicrotubule agent. Learn more at Thermo Fisher Scientific.

Fórmula: C₄₃H₅₃NO₁₄

Pureza: 99%

Peso molecular: 807.89

Ref: 02-J60174

ANHYDROUS DOCETAXEL CRS

CAS: 114977-28-5

ANHYDROUS DOCETAXEL CRS

Fórmula: C₄₃H₅₃NO₁₄

Cor e Forma: Crystalline Powder. White. Powder.

Peso molecular: 807.8792

Ref: 41-Y0001466

Docetaxel

CAS: 114977-28-5

Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM).

Fórmula: C₄₃H₅₃NO₁₄

Pureza: 98.6% - 99.29%

Cor e Forma: Off-White Cryst

Peso molecular: 807.88

Ref: TM-T1034

Docetaxel

CAS: 114977-28-5

Fórmula: C₄₃H₅₃NO₁₄

Pureza: %

Cor e Forma: Solid

Peso molecular: 807.8792

Ref: IN-DA0039I1

Docetaxel

CAS: 114977-28-5

Fórmula: C₄₃H₅₃NO₁₄·xH₂O

Pureza: ≤ 0.1%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 807.88 (anhydrous)

Ref: 7W-GP5102

Docetaxel

CAS: 114977-28-5

Docetaxel

Fórmula: C₄₃H₅₃NO₁₄

Pureza: >99%

Cor e Forma: white crystalline solid or powder

Peso molecular: 807.87922g/mol

Ref: 54-BID2710

Docetaxel

CAS: 114977-28-5

Fórmula: C₄₃H₅₃NO₁₄

Cor e Forma: White To Off-White Solid

Peso molecular: 807.89

Ref: 4Z-D-191

Docetaxel Anhydrous

Produto Controlado

CAS: 114977-28-5

Fórmula: C₄₃H₅₃NO₁₄

Cor e Forma: Neat

Peso molecular: 807.88

Ref: 86-MM3390.00

Docetaxel

CAS: 114977-28-5

Docetaxel is an antineoplastic drug by inhibiting microtubule depolymerization, and attenuating of the effects of bcl-2 and bcl-xL gene expression.

Fórmula: C₄₃H₅₃NO₁₄

Pureza: 95%~99%

Peso molecular: 807.89

Ref: BP-BP0514

Docetaxel

CAS: 114977-28-5

Applications Docetaxel is an antimitotic Taxol analog antibiotic.

Fórmula: C₄₃H₅₃NO₁₄

Cor e Forma: Off White Solid

Peso molecular: 807.88

Ref: TR-D525623

Docetaxel

CAS: 114977-28-5

A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.

Fórmula: C₄₃H₅₃NO₁₄

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 807.88 g/mol

Ref: 3D-FD10817

Docetaxel - Bio-X ™

CAS: 114977-28-5

Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.

Fórmula: C₄₃H₅₃NO₁₄

Pureza: Min. 90 Area-%

Cor e Forma: White/Off-White Solid

Peso molecular: 807.88 g/mol

Ref: 3D-BD164373

Docetaxel Anhydrous

CAS: 114977-28-5

Cor e Forma: Neat

Ref: 61-FOR3390.00