CAS 115966-23-9

Urodilatina

Descrição:

Urodilatina é um peptídeo derivado da pro-hormona pro-peptídeo natriurético atrial (pro-ANP) e está principalmente envolvido na regulação da função renal e do equilíbrio de fluidos. É caracterizado por seu papel como agente natriurético, promovendo a excreção de sódio e água, o que ajuda a reduzir o volume sanguíneo e a baixar a pressão arterial. Urodilatina é produzido nos rins e atua nos túbulos renais, aumentando a diurese e a natriurese. Sua estrutura consiste em uma sequência de aminoácidos que conferem sua atividade biológica, e é conhecido por interagir com receptores específicos no corpo, levando à vasodilatação e ao aumento da taxa de filtração glomerular. O potencial terapêutico de Urodilatina está sendo explorado em condições como insuficiência cardíaca e hipertensão, onde a sobrecarga de fluidos é uma preocupação. No geral, suas propriedades únicas fazem dele uma molécula importante na fisiologia cardiovascular e renal.

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

InChI: InChI=1/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167,207)(H,168,216)(H,169,215)(H,170,217)(H,171,238)(H,172,208)(H,173,237)(H,174,209)(H,175,210)(H,176,211)(H,177,214)(H,178,219)(H,179,226)(H,180,227)(H,181,229)(H,182,218)(H,183,236)(H,184,230)(H,185,235)(H,186,231)(H,187,234)(H,188,224)(H,189,220)(H,190,223)(H,191,222)(H,192,221)(H,193,228)(H,194,232)(H,195,233)(H,196,225)(H,212,213)(H,240,241)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)/t72-,73-,74-,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-/m0/s1

Sinónimos:

• Anp 95-126
• H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond)
• Proatrial natriuretic peptide (95-126)
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human)
• Urodilatin
• Urodilatin (CDD/ANP-95-126)
• THR-ALA-PRO-ARG-ATRIAL NATRIURETIC PEPTIDE
• URODILATIN CCC/ANP, 95-126
• Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide, Urodilatin, human
• H-THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR-OH (DISULFIDE BRIDGE: 11-27)
• Urodilatin CCC
• THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR(DISULFIDE BRIDGE CYS11- CYS 27)
• TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY (DISULFIDE BRIDGE: 11-27)
• THR-ALA-PRO-ARG-ATRIAL NATRIURETIC PEPTIDE HUMAN
• THR-ALA-PRO-ARG-ANP, HUMAN
• CCC/ANP-95-126
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (huMan, bovine, porcine)
• URODILATIN HUMAN
• URODILATIN (95-126)
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt
• THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR
• Urodilatin, Ularitide
• CDD/ANP-95-126

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine)

CAS: 115966-23-9

Urodilatin, a 32 amino acid peptide, has originally been isolated from human urine. It belongs to the family of natriuretic-vasorelaxant peptides earlier found in heart atria. Cedidi et al. showed that urodilatin infusion may represent a concept for the treatment of therapy-resistant acute renal failure after liver transplantation. The use of ularitide is protected by patents. It is sold by Bachem for research purposes only, by expressed permission of Pharis Biotec GmbH, Hannover, Germany (www.pharis-biotec.com).

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Pureza: ≥ 95%

Cor e Forma: White Powder

Peso molecular: 3505.98

Ref: 01-4030382

Urodilatin

CAS: 115966-23-9

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Pureza: 95%

Peso molecular: 3505.9265

Ref: IN-DA000H8N

Urodilatin

CAS: 115966-23-9

Urodilatin, an analogue of ANF-(99-126), serves as a diuretic-natriuretic regulatory peptide with applications in the study of acute renal failure, congestive

Cor e Forma: Solid

Ref: TM-T80891

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt

CAS: 115966-23-9

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt is a peptide hormone that regulates blood pressure by causing the kidneys to excrete sodium and water. It is used as a model system for studying the physiological effects of urodilatin and has been shown to inhibit the cyclase enzyme. Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt may also have an antihypertensive effect through its ability to reduce levels of natriuretic peptides in plasma. This drug is also being investigated as a possible treatment for congestive heart failure. The small molecular weight makes it suitable for use as a natriuretic or antihypertensive drug with minimal side effects.

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Pureza: Min. 95%

Peso molecular: 3,505.93 g/mol

Ref: 3D-FT108857