CAS 117399-94-7

endotelina 1

Descrição:

A endotelina-1 (ET-1) é um potente peptídeo vasoconstritor que desempenha um papel crucial em vários processos fisiológicos e patológicos, particularmente no sistema cardiovascular. É um peptídeo de 21 aminoácidos produzido principalmente por células endoteliais e está envolvido na regulação da pressão arterial, do tônus vascular e do equilíbrio de fluidos. A ET-1 é conhecida por sua capacidade de induzir a contração do músculo liso e promover a proliferação celular, tornando-a significativa em condições como hipertensão e insuficiência cardíaca. O peptídeo exerce seus efeitos através de receptores específicos, principalmente o receptor de endotelina tipo A (ETA) e tipo B (ETB), que estão distribuídos por todo o corpo. Além de seus efeitos cardiovasculares, a endotelina-1 está implicada em vários outros processos biológicos, incluindo inflamação, crescimento celular e neurobiologia. Devido aos seus efeitos potentes, a ET-1 é um alvo para intervenções terapêuticas em doenças caracterizadas por vasoconstrição excessiva e remodelação tecidual. Seu número CAS, 117399-94-7, é usado para identificação em bancos de dados químicos e contextos regulatórios.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

InChI: InChI=1/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)

SMILES: CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)CC)N=C(C(CC(=O)O)N=C(C(CC(C)C)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(CO)C(=NC2CSSCC(C(=NC(C(C)C)C(=NC(Cc3ccc(cc3)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCCCN)N=C(C(CC(=O)O)N=C(C(CCSC)N=C(C(CC(C)C)N=C(C(CO)N=C(C(CO)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O

Sinónimos:

• Endothelin 1 human, porcine
• H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)
• Endothelin 1, Human and Porcine
• Endothelin-1,Human
• Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt

Endothelin-1 (human, bovine, dog, mouse, porcine, rat)

CAS: 117399-94-7

Endothelin-1 (ET-1) is a potent vasoconstrictive 21-amino acid peptide produced by endothelia cells. It acts on endothelia cells and on the underlying smooth muscle cells as a modulator of vascular tone. ET-1 shows selectivity for the ET-A receptor.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pureza: 95.0%

Cor e Forma: White

Peso molecular: 2491.94

Ref: 01-4048904

Endothelin-1 (human, bovine, dog, mouse, porcine, rat)

CAS: 117399-94-7

Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pureza: 91.90%

Cor e Forma: White

Peso molecular: 2491.94

Ref: 01-4040254

Endothelin-1 Acetate

CAS: 117399-94-7

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 2491.9

Ref: BP-BPPG025

Endothelin 1 (swine, human)

CAS: 117399-94-7

Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Cor e Forma: White Powder

Peso molecular: 2491.9

Ref: TM-T19309

Endothelin-1

CAS: 117399-94-7

Endothelin-1

Cor e Forma: White Powder

Peso molecular: 2,491.90g/mol

Ref: 54-BIBA1014

Endothelin-1 (Human)

CAS: 117399-94-7

Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.1mg vial.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pureza: Min. 95%

Peso molecular: 2,491.9 g/mol

Ref: 3D-PED-4198-S

Endothelin-1 (Human)

CAS: 117399-94-7

Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.
This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.5mg vial.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Pureza: Min. 95%

Peso molecular: 2,491.9 g/mol

Ref: 3D-PED-4198-V

Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate

CAS: 117399-94-7

Endothelin-1 (ET-1) is a peptide that is produced by the endothelium. ET-1 is involved in numerous biological processes, including vasoconstriction, inflammation, and cell proliferation. Endothelin-1 (human ET-1) acetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-(Glu)-Cys-(Val)-Tyr-(Phe)-Cys-(His)-Leu -Asp(-Ile)-Ile(-Trp)) acetate salt is a recombinant protein that has been shown to significantly upregulate the production of endothelin in primary pulmonary hypertension. It also plays an important role in bowel disease, where it may be involved in the development of chronic inflammatory bowel disease.

Fórmula: C₁₀₉H₁₅₉N₂₅O₃₂S₅•(C₂H₄O₂)x

Pureza: Min. 95%

Peso molecular: 2,491.91 g/mol

Ref: 3D-FE109997