CAS 1177806-11-9

L-744832

Produto Controlado

CAS: 1177806-11-9

Applications Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
References Barrington, R.E., et al.: Mol. Cell. Biol., 18, 85 (1998, Sepp-Lorenzo, L. and Rosen, N.: J. Biol. Chem., 273, 20243 (1998), Moasser, M.M., et al.: Proc. Natl. Acad. Sci. USA, 95, 1369 (1998), Law, B.K., et al.: J. Biol. Chem., 275, 10796 (2000),

Fórmula: C₂₆H₄₇Cl₂N₃O₆S₂

Cor e Forma: Neat

Peso molecular: 559.78

Ref: TR-L744832