CAS 118414-82-7

MK-886

Descrição:

MK-886, com o número CAS 118414-82-7, é um composto sintético que funciona principalmente como um inibidor seletivo da enzima 5-lipoxigenase (5-LO). Esta enzima desempenha um papel crucial na biossíntese de leucotrienos, que são mediadores inflamatórios envolvidos em várias condições patológicas, incluindo asma e outras doenças inflamatórias. MK-886 é caracterizado por sua capacidade de modular respostas inflamatórias, tornando-se um assunto de interesse na pesquisa farmacológica. O composto é tipicamente estudado por suas potenciais aplicações terapêuticas no tratamento de condições associadas à produção excessiva de leucotrienos. Em termos de sua estrutura química, MK-886 apresenta uma disposição distinta de grupos funcionais que contribuem para sua atividade biológica. É importante notar que, embora MK-886 tenha mostrado promessas em estudos pré-clínicos, mais pesquisas são necessárias para entender completamente sua eficácia, perfil de segurança e potenciais aplicações clínicas. Assim como muitos compostos investigacionais, seu uso está principalmente confinado a ambientes de pesquisa até que dados clínicos mais definitivos estejam disponíveis.

Fórmula: C₂₇H₃₃ClNO₂S·Na

InChI: InChI=1/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31)

Chave InChI: InChIKey=QAOAOVKBIIKRNL-UHFFFAOYSA-N

SMILES: C(N1C=2C(C(SC(C)(C)C)=C1CC(C(O)=O)(C)C)=CC(C(C)C)=CC2)C3=CC=C(Cl)C=C3

Sinónimos:

• 1-((4-Chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-
• 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-
• 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid
• 3-[3-(butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• L 663536
• MK 886
• MK 886
• CGS-81585
• 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
• 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt
• MK866
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid
• MK-886 (L-663,536)
• MK-886 (Free Base)

1H-Indole-2-propanoic acid,1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-

CAS: 118414-82-7

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 472.0824

Ref: IN-DA008RN6

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

CAS: 118414-82-7

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

Pureza: 98%

Peso molecular: 472.08g/mol

Ref: 54-OR1026587

MK-886

CAS: 118414-82-7

MK-886

Pureza: ≥98%

Peso molecular: 472.08g/mol

Ref: 54-BUP07765

MK-886

CAS: 118414-82-7

MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: 99.23% - 99.84%

Cor e Forma: Solid

Peso molecular: 472.08

Ref: TM-T6893

MK-886

CAS: 118414-82-7

MK-886 is a synthetic compound, formally classified as a leukotriene biosynthesis inhibitor, which is derived through chemical synthesis processes. This compound acts by specifically targeting the 5-lipoxygenase-activating protein (FLAP), a crucial component in the leukotriene synthesis pathway. By inhibiting FLAP, MK-886 effectively suppresses the production of leukotrienes, which are lipid compounds that play a pivotal role in the inflammatory response.

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 472.08 g/mol

Ref: 3D-TEA41482

MK 886 - Bio-X ™

CAS: 118414-82-7

MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 472.08 g/mol

Ref: 3D-BM166037

MK-886

Produto Controlado

CAS: 118414-82-7

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.
References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);

Fórmula: C₂₇H₃₄ClNO₂S

Cor e Forma: Neat

Peso molecular: 472.08

Ref: TR-M425053