CAS 118506-26-6

Proteína Básica da Mielina (87-99) (humano, bovino, rato)

Descrição:

A proteína básica de mielina (MBP) é um componente crucial da bainha de mielina que isola as fibras nervosas no sistema nervoso central. O fragmento específico denominado 'Proteína Básica de Mielina (87-99)' corresponde a uma sequência peptídica derivada da proteína de comprimento total, que desempenha um papel significativo na formação e manutenção da mielina. Esta proteína é caracterizada por sua alta basicidade, devido à presença de numerosos aminoácidos carregados positivamente, o que facilita sua interação com lipídios carregados negativamente na membrana de mielina. A MBP é essencial para o funcionamento adequado dos oligodendrócitos, as células responsáveis pela mielinização no sistema nervoso central. Também está envolvida em vários processos celulares, incluindo sinalização e organização do citoesqueleto. O número CAS 118506-26-6 identifica este peptídeo específico, que pode ser derivado de várias espécies, incluindo humanos, bovinos e ratos, refletindo sua conservação evolutiva e importância em diferentes organismos. A pesquisa sobre a MBP é significativa para entender doenças desmielinizantes, como a esclerose múltipla, onde o sistema imunológico ataca erroneamente a mielina.

Fórmula: C₇₄H₁₁₄N₂₀O₁₇

Sinónimos:

• Myelin Basic Protein (87-99), Guinea Pig, Human
• Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro
• Vhffknivtprtp
• Mbp (Human, Bovine, Rat)
• Mbp (87-99) Human
• H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-Oh (Human, Bovine, Rat)

Myelin Basic Protein (87-99)

CAS: 118506-26-6

The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur. This can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.
Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways.
Although more research needs to be carried out, it is thought that MBP significantly contributes to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased in and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.

Fórmula: C₇₄H₁₁₄N₂₀O₁₇

Pureza: Min. 95%

Peso molecular: 1,555.86 g/mol

Ref: 3D-PMB-3973-PI

Myelin Basic Protein (87-99) (human, bovine, rat)

CAS: 118506-26-6

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₇₄H₁₁₄N₂₀O₁₇

Peso molecular: 1,555.84 g/mol

Ref: 3D-PP49994

Myelin Basic Protein (87-99) (human, bovine, rat)

CAS: 118506-26-6

Please enquire for more information about Myelin Basic Protein (87-99) (human, bovine, rat) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fórmula: C₇₄H₁₁₄N₂₀O₁₇

Pureza: Min. 95%

Peso molecular: 1,555.82 g/mol

Ref: 3D-FM108566

Myelin Basic Protein (87-99) (human, bovine, rat)

CAS: 118506-26-6

This MBP fragment has been shown to induce the proliferation of an encephalitogenic, myelin basic protein-specific T cell line. Active immunization of rats with this peptide induced acute experimental autoimmune encephalomyelitis. This protein region is highly conserved among mammalian species.

Fórmula: C₇₄H₁₁₄N₂₀O₁₇

Pureza: 100%

Cor e Forma: White Lyophilisate

Peso molecular: 1555.84

Ref: 01-4025349