CAS 120202-71-3

(R)-Clopidogrel bissulfato

Descrição:

(R)-Clopidogrel bissulfato é um medicamento antiplaquetário usado principalmente para prevenir coágulos sanguíneos em pacientes com doenças cardiovasculares. É um pró-fármaco que requer ativação metabólica para exercer seus efeitos terapêuticos, inibindo especificamente o receptor P2Y12 nas plaquetas, evitando assim a agregação plaquetária. O composto é caracterizado por sua natureza quiral, sendo o enantiômero (R) a forma ativa responsável por sua atividade farmacológica. O bisulfato de clopidogrel é tipicamente administrado por via oral e é bem absorvido no trato gastrointestinal, embora sua biodisponibilidade seja afetada pelo metabolismo de primeira passagem. A substância é frequentemente formulada como um sal de bisulfato para melhorar sua solubilidade e estabilidade. Os efeitos colaterais comuns incluem complicações hemorrágicas, distúrbios gastrointestinais e, em casos raros, reações de hipersensibilidade. Devido ao seu mecanismo de ação, é crucial que os pacientes sejam monitorados quanto a sinais de sangramento, especialmente quando usados em conjunto com outros anticoagulantes ou agentes antiplaquetários. No geral, (R)-Clopidogrel bissulfato desempenha um papel significativo no manejo de distúrbios trombóticos.

Fórmula: C₁₆H₁₆ClNO₂S·H₂O₄S

InChI: InChI=1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m1./s1

Chave InChI: InChIKey=FDEODCTUSIWGLK-XFULWGLBSA-N

SMILES: [C@@H](C(OC)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.S(=O)(=O)(O)O

Sinónimos:

• (R)-(-)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate bisulfate
• (R)-(-)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogen sulfate
• (R)-Clopidogrel bisulfate
• (R)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
• Clopidogrel Related Compound C
• Methyl(-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate
• Sr 25989C
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αR)-, sulfate (1:1)
• methyl (2R)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate sulfate

Clopidogrel Related Compound C (methyl (-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate)

CAS: 120202-71-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₆H₁₆ClNO₂S·H₂SO₄

Cor e Forma: White Powder

Peso molecular: 321.05903

Ref: 45-1140600

(R)-Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7h)-yl)acetate sulfate

CAS: 120202-71-3

Fórmula: C₁₆H₁₈ClNO₆S₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 419.9002

Ref: IN-DA0081B8

Clopidogrel EP Impurity C Sulfate (Clopidogrel USP Related Compound C, (R)-Clopidogrel Sulfate)

CAS: 120202-71-3

Fórmula: C₁₆H₁₆ClNO₂S·H₂SO₄

Cor e Forma: White To Off-White Solid

Peso molecular: 321.82 98.07

Ref: 4Z-C-1314

Clopidogrel Related Compound C

CAS: 120202-71-3

Clopidogrel Related Compound C

Pureza: ≥95%

Peso molecular: 419.89g/mol

Ref: 54-BUP18818

Methyl (2R)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetate Hydrogen Sulfate ((R)-Clopidogrel Hydrogen Sulfate)

CAS: 120202-71-3

Cor e Forma: Neat

Ref: 86-MM0455.12

Clopidogrel Related Compound C

CAS: 120202-71-3

(R)-Clopidogrel bisulfate (Clopidogrel Related Compound C) is an isomer of clopidogrel. Clopidogrel is a P2Y12 receptor antagonist.

Fórmula: C₁₆H₁₈ClNO₆S₂

Pureza: 97.84%

Cor e Forma: Solid

Peso molecular: 419.9

Ref: TM-T126236

R-(-)-Clopidogrel Hydrogen Sulfate

Produto Controlado

CAS: 120202-71-3

Impurity Clopidogrel EP Impurity C
Stability Very Hygroscopic
Applications R-(-)-Clopidogrel Hydrogen Sulfate (Clopidogrel EP Impurity C) is used as an antithrombotic. Clopidogrel Related Compound C
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)

Fórmula: C₁₆H₁₆ClNO₂S·H₂O₄S

Cor e Forma: White

Peso molecular: 419.90

Ref: TR-C587251

Clopidogrel EP Impurity C

CAS: 120202-71-3

Fórmula: C₁₆H₁₆ClNO₂SH₂O₄S

Peso molecular: 321.8 : 98.1

Ref: ST-EA-CP-C2003

R-(-)-Clopidogrel hydrogen sulfate

CAS: 120202-71-3

R-(-)-Clopidogrel hydrogen sulfate is a prodrug of clopidogrel, which is an antiplatelet agent. It is used to prevent thrombotic events in people with coronary artery disease, peripheral arterial disease, or cerebrovascular disease. The drug is broken down in the liver and then converted to an active form by the enzyme CYP2C19. The R-(-)-isomer of clopidogrel has been shown to be more effective for reducing platelet aggregation than its S-enantiomer, with no difference in effectiveness between the two forms for reducing heart attacks and strokes. This drug can be found in wastewater samples due to its use as a therapeutic agent. The method used for analysis was LC-MS/MS and the excipients were not reported.

Fórmula: C₁₆H₁₈ClNO₆S₂

Pureza: Min. 98 Area-%

Cor e Forma: White Slightly Yellow Powder

Peso molecular: 419.02641

Ref: 3D-FC20512