CAS 120972-53-4

sarafotoxina S6B

Descrição:

sarafotoxina S6B é uma potente neurotoxina derivada do veneno da cobra africana, a mamba. Pertence a uma classe de peptídeos conhecidos como sarafotoxinas, que são estruturalmente relacionados às endotelinas e exibem atividade biológica significativa. sarafotoxina S6B atua principalmente como um vasoconstritor, influenciando a contração dos vasos sanguíneos e potencialmente levando ao aumento da pressão arterial. Seu mecanismo de ação envolve a ligação aos receptores de endotelina, particularmente o subtipo ET_A, que desempenha um papel crucial na regulação cardiovascular. A substância é caracterizada por sua alta afinidade por esses receptores, tornando-a uma ferramenta valiosa para estudar interações de receptores e vias de sinalização. Além disso, sarafotoxina S6B tem sido investigada por suas potenciais implicações em farmacologia e toxicologia, particularmente na compreensão dos efeitos dos componentes do veneno de cobra na fisiologia humana. Devido aos seus potentes efeitos biológicos, é essencial manusear essa substância com cautela em ambientes de laboratório.

Fórmula: C₁₁₀H₁₅₉N₂₇O₃₄S₅

InChI: InChI=1/C110H162N26O35S5/c1-9-55(6)88(108(168)134-87(54(4)5)107(167)129-77(110(170)171)40-59-45-115-64-22-14-13-21-62(59)64)135-102(162)76(44-86(148)149)127-93(153)67(29-31-82(140)141)120-99(159)73(41-60-46-114-52-116-60)125-106(166)81(51-175)132-98(158)71(38-57-19-11-10-12-20-57)124-97(157)72(39-58-25-27-61(139)28-26-58)123-96(156)70(37-53(2)3)122-105(165)80(50-174)131-94(154)68(30-32-83(142)143)119-91(151)65(23-15-17-34-111)117-101(161)75(43-85(146)147)128-109(169)89(56(7)138)136-95(155)69(33-36-176-8)121-100(160)74(42-84(144)145)126-92(152)66(24-16-18-35-112)118-104(164)79(49-173)133-103(163)78(47-137)130-90(150)63(113)48-172/h10-14,19-22,25-28,45-46,52-56,63,65-81,87-89,115,137-139,172-175H,9,15-18,23-24,29-44,47-51,111-113H2,1-8H3,(H,114,116)(H,117,161)(H,118,164)(H,119,151)(H,120,159)(H,121,160)(H,122,165)(H,123,156)(H,124,157)(H,125,166)(H,126,152)(H,127,153)(H,128,169)(H,129,167)(H,130,150)(H,131,154)(H,132,158)(H,133,163)(H,134,168)(H,135,162)(H,136,155)(H,140,141)(H,142,143)(H,144,145)(H,146,147)(H,148,149)(H,170,171)/t55-,56+,63-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,87-,88-,89-/m0/s1

Sinónimos:

• Sarafotoxin S6b, Atractaspsisengaddensis
• Csckdmtdkeclyfchqdviw
• Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp
• H-Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-Oh
• H-Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-Oh-Oh
• Sarafotoxin S6B (Atractaspis Engaddensis)
• Sarafotoxin S6B Atractaspis Engaddensis Sequence
• Sarafotoxin B

Sarafotoxin S6b

CAS: 120972-53-4

Sarafotoxin S6b, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction.
As the most potent Sarafotoxin, sarafotoxin S6b binds to both ETA and ETB receptors with a similar affinity to Endothelin-1. This is evident as when given to mice intravenously, sarafotoxin S6b caused cardiac arrest and death in mice almost immediately. Additional characteristics of S6b is its matrix metalloproteinase inhibitory activity due to it exhibiting a fold which is also found in the core region of tissue inhibitors of metalloproteinases (TIMPs).
Sarafotoxin S6b can be used as a pharmacological reagent to study the interactions of Endothelins and their corresponding receptors. This product is available as a 0.1mg vial.

Fórmula: C₁₁₀H₁₅₉N₂₇O₃₄S₅

Pureza: Min. 95%

Peso molecular: 2,563.9 g/mol

Ref: 3D-PSF-4206-S

Sarafotoxin B trifluoroacetate salt

CAS: 120972-53-4

Component of snake venom; part of a family of vasoconstrictor isopeptides

Fórmula: C₁₁₀H₁₅₉N₂₇O₃₄S₅

Pureza: Min. 95%

Peso molecular: 2,563.93 g/mol

Ref: 3D-FS110266