CAS 120993-53-5

Desirudina

Descrição:

Desirudina é um anticoagulante sintético que pertence à classe dos inibidores diretos da trombina. É utilizado principalmente na prevenção e tratamento da tromboembolismo venoso, particularmente em pacientes submetidos a cirurgia ortopédica. Desirudina funciona ligando-se especificamente à trombina, inibindo sua atividade e, assim, prevenindo a conversão de fibrinogênio em fibrina, que é uma etapa crucial no processo de coagulação do sangue. A substância é caracterizada por sua meia-vida relativamente curta, exigindo dosagem e administração cuidadosas, muitas vezes por meio de injeção subcutânea. Desirudina é solúvel em água, o que facilita seu uso em ambientes clínicos. Sua farmacocinética pode ser influenciada por fatores como a função renal, tornando o monitoramento importante em certas populações de pacientes. Assim como outros anticoagulantes, há um risco de sangramento, e seu uso requer consideração cuidadosa das potenciais interações medicamentosas e contraindicações. No geral, Desirudina representa uma opção terapêutica importante no manejo de distúrbios trombóticos.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₀S₆

InChI: InChI=1/C287H440N80O110S6/c1-25-133(19)226-281(470)345-161(87-125(3)4)235(424)306-111-208(395)320-180(116-370)266(455)344-175(101-219(415)416)237(426)307-105-202(389)316-151(62-75-212(401)402)242(431)321-145(41-30-33-81-288)240(429)339-170(96-197(297)384)258(447)326-152(57-70-193(293)380)249(438)351-185(121-481-478-118-182-239(428)310-107-201(388)313-147(55-68-191(291)378)232(421)303-108-205(392)317-169(95-196(296)383)257(446)322-146(42-31-34-82-289)241(430)350-186(271(460)360-226)122-482-479-119-183(268(457)323-149(61-74-211(399)400)234(423)304-110-207(394)319-179(115-369)265(454)342-173(99-200(300)387)264(453)357-223(130(13)14)279(468)355-182)352-253(442)164(90-128(9)10)335-269(458)184-120-480-483-123-187(354-262(451)177(103-221(419)420)347-283(472)230(137(23)374)362-263(452)167(93-141-49-53-144(377)54-50-141)346-278(467)224(131(15)16)359-276(465)222(301)129(11)12)272(461)363-229(136(22)373)282(471)330-157(66-79-216(409)410)248(437)348-178(114-368)238(427)309-106-203(390)315-150(56-69-192(292)379)243(432)340-171(97-198(298)385)259(448)334-163(89-127(7)8)252(441)353-184)270(459)358-225(132(17)18)280(469)364-228(135(21)372)277(466)311-112-204(391)314-148(60-73-210(397)398)233(422)305-113-209(396)356-231(138(24)375)286(475)367-86-38-46-190(367)275(464)331-159(43-32-35-83-290)284(473)365-84-36-44-188(365)273(462)328-153(58-71-194(294)381)247(436)349-181(117-371)267(456)338-168(94-142-104-302-124-312-142)256(445)341-172(98-199(299)386)260(449)343-174(100-218(413)414)236(425)308-109-206(393)318-176(102-220(417)418)261(450)337-165(91-139-39-28-27-29-40-139)254(443)327-154(63-76-213(403)404)244(433)325-158(67-80-217(411)412)250(439)361-227(134(20)26-2)285(474)366-85-37-45-189(366)274(463)329-156(65-78-215(407)408)245(434)324-155(64-77-214(405)406)246(435)336-166(92-140-47-51-143(376)52-48-140)255(444)333-162(88-126(5)6)251(440)332-160(287(476)477)59-72-195(295)382/h27-29,39-40,47-54,104,124-138,145-190,222-231,368-377H,25-26,30-38,41-46,55-103,105-123,288-290,301H2,1-24H3,(H2,291,378)(H2,292,379)(H2,293,380)(H2,294,381)(H2,295,382)(H2,296,383)(H2,297,384)(H2,298,385)(H2,299,386)(H2,300,387)(H,302,312)(H,303,421)(H,304,423)(H,305,422)(H,306,424)(H,307,426)(H,308,425)(H,309,427)(H,310,428)(H,311,466)(H,313,388)(H,314,391)(H,315,390)(H,316,389)(H,317,392)(H,318,393)(H,319,394)(H,320,395)(H,321,431)(H,322,446)(H,323,457)(H,324,434)(H,325,433)(H,326,447)(H,327,443)(H,328,462)(H,329,463)(H,330,471)(H,331,464)(H,332,440)(H,333,444)(H,334,448)(H,335,458)(H,336,435)(H,337,450)(H,338,456)(H,339,429)(H,340,432)(H,341,445)(H,342,454)(H,343,449)(H,344,455)(H,345,470)(H,346,467)(H,347,472)(H,348,437)(H,349,436)(H,350,430)(H,351,438)(H,352,442)(H,353,441)(H,354,451)(H,355,468)(H,356,396)(H,357,453)(H,358,459)(H,359,465)(H,360,460)(H,361,439)(H,362,452)(H,363,461)(H,364,469)(H,397,398)(H,399,400)(H,401,402)(H,403,404)(H,405,406)(H,407,408)(H,409,410)(H,411,412)(H,413,414)(H,415,416)(H,417,418)(H,419,420)(H,476,477)/t133-,134-,135+,136+,137+,138+,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,222-,223-,224-,225-,226-,227-,228-,229-,230-,231-/m0/s1

Sinónimos:

• Desirudin [USAN:INN]
• 63-Desulfohirudin (Hirudo medicinalis isoform HV1)
• Cgp 39393
• Iprivask
• Revasc
• Unii-U0Jz726775
• Hirudin (Hirudo medicinalis isoform HV1), 63-desulfo-

Desirudin

CAS: 120993-53-5

Desirudin is a recombinant human coagulation factor that has been used as an anticoagulant in patients with liver impairment. Desirudin is a single-chain polypeptide composed of the signal peptide and the active protein, which is cleaved from the pro-protein during translation. The activity of desirudin is dependent on intramolecular hydrogen bonding and it inhibits thrombin by binding to its active site. Desirudin has been shown to have a protective effect against experimental myocardial infarction in rats with congestive heart failure. This drug also has pharmacokinetic properties that are dependent on body mass index and glomerular filtration rate, which may affect its efficacy in patients with different conditions.

Fórmula: C₂₈₇H₄₄₀N₈₀O₁₁₀S₆

Pureza: Min. 95%

Peso molecular: 6,963.43 g/mol

Ref: 3D-FD170616

Desirudin

CAS: 120993-53-5

Desirudin (CGP 39393) inhibits thrombin, prevents thrombosis, and is used in thrombocytopenia research.

Cor e Forma: Solid

Ref: TM-T64250