CAS 121695-87-2

Sarafotoxina S6C

Descrição:

Sarafotoxina S6C é uma toxina peptídica derivada do veneno de certas espécies de cobras, particularmente aquelas da família Viperidae. É conhecida por sua potente atividade biológica, principalmente como uma neurotoxina que afeta o sistema cardiovascular. Sarafotoxina S6C exibe alta afinidade por receptores específicos, levando à vasoconstrição e ao aumento da pressão arterial. Sua estrutura geralmente inclui uma série de aminoácidos dispostos em uma sequência específica, contribuindo para sua estabilidade e atividade. A toxina é frequentemente estudada por suas potenciais implicações em farmacologia e toxicologia, pois pode fornecer insights sobre interações de receptores e vias de sinalização. Além disso, devido aos seus efeitos biológicos, Sarafotoxina S6C é de interesse na pesquisa relacionada à hipertensão e outros distúrbios cardiovasculares. Precauções de segurança são essenciais ao manusear esta substância, pois pode representar riscos significativos à saúde. No geral, Sarafotoxina S6C serve como um modelo valioso para entender os mecanismos das toxinas peptídicas e suas potenciais aplicações terapêuticas.

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

InChI: InChI=1/C103H147N27O37S5/c1-10-46(6)80(100(163)123-67(103(166)167)30-50-37-109-54-19-15-14-18-52(50)54)128-99(162)79(45(4)5)127-95(158)66(36-78(144)145)120-85(148)55(20-23-71(105)133)112-90(153)61(31-51-38-108-43-110-51)117-97(160)69-40-170-169-39-53(104)83(146)129-81(47(7)131)102(165)126-70-42-172-171-41-68(96(159)115-59(28-44(2)3)88(151)118-62(32-72(106)134)91(154)116-60(89(152)125-69)29-49-16-12-11-13-17-49)124-86(149)57(22-25-75(138)139)111-84(147)56(21-24-74(136)137)113-94(157)65(35-77(142)143)122-101(164)82(48(8)132)130-87(150)58(26-27-168-9)114-93(156)64(34-76(140)141)121-92(155)63(33-73(107)135)119-98(70)161/h11-19,37-38,43-48,53,55-70,79-82,109,131-132H,10,20-36,39-42,104H2,1-9H3,(H2,105,133)(H2,106,134)(H2,107,135)(H,108,110)(H,111,147)(H,112,153)(H,113,157)(H,114,156)(H,115,159)(H,116,154)(H,117,160)(H,118,151)(H,119,161)(H,120,148)(H,121,155)(H,122,164)(H,123,163)(H,124,149)(H,125,152)(H,126,165)(H,127,158)(H,128,162)(H,129,146)(H,130,150)(H,136,137)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)

SMILES: CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(CCC(=N)O)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(C(C)O)C(=NC2CSSCC(C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCC(=O)O)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(CCSC)N=C(C(CC(=O)O)N=C(C(CC(=N)O)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O

Sinónimos:

• Srtx-C
• Sarafotoxin S6C (Atractaspis Engaddensis)
• Sarafotoxin S6C, Atractaspsis Engaddensis
• Sarafotoxin 6C
• Sarafotoxin C
• Sarafotoxin C (Atractaspis Engaddensis)
• Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp

Sarafotoxin C

CAS: 121695-87-2

Highly selective ET-B receptor agonist.

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: > 95%

Cor e Forma: White Powder

Peso molecular: 2515.79

Ref: 01-4031255

Sarafotoxin S6c

CAS: 121695-87-2

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 2516

Ref: TM-TP2120

Sarafotoxin S6c

CAS: 121695-87-2

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: ≥ 95.0%

Cor e Forma: White lyophilised powder

Peso molecular: 2515.75

Ref: 7W-GK0055

Sarafotoxin S6c

CAS: 121695-87-2

Sarafotoxin S6c, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.
Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction. Compared to the sarafotoxin isopeptide S6b, S6c is less toxic with a 100 to 10,000-fold reduced affinity for the ETA receptor, therefore acts as a selective agonist to the ETB receptor. One study demonstrated that when sarafotoxin 6c was used to activate ETB receptors in rats there was an increase in arterial pressure, known as S6c-induced hypertension.
As the upregulation of Endothelin-1 (ET-1) is related to circulatory-system diseases, the interaction between ET-1 and its receptors is highly important for development of endothelin receptor antagonist treatments. Sarafotoxin S6c can be used as a pharmacological reagent to study these interactions.

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: Min. 95%

Peso molecular: 2,515.8 g/mol

Ref: 3D-PSF-4246-S

Sarafotoxin C trifluoroacetate salt

CAS: 121695-87-2

Sarafotoxin C is a peptide from the venom of the spider Phoneutria nigriventer that has been shown to have potent inhibitory properties on endothelin-1. Sarafotoxin C is able to block intracellular Ca2+ levels and signal pathways, leading to decreased levels of endothelin-1 as well as other inflammatory mediators. Sarafotoxin C has also been shown to have an anti-inflammatory effect in bowel disease, which may be due to its ability to inhibit the production of cytokines and prostaglandins. The biological properties of sarafotoxin C are related to its inhibition of polymerase chain reaction (PCR) amplification of DNA. This inhibition is due to the binding of sarafotoxin C with endothelin receptors on DNA, which prevents DNA polymerase from attaching. Endothelin-a receptor activity can also be inhibited by sarafotoxin C through enzymatic inactivation. Sarafot

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: Min. 95%

Peso molecular: 2,515.76 g/mol

Ref: 3D-FS110267