CAS 123318-82-1

Clofarabina

Descrição:

Clofarabina é um análogo de nucleosídeo sintético usado principalmente no tratamento da leucemia linfoblástica aguda (LLA) e da leucemia mieloide aguda (LMA). É caracterizado por sua estrutura, que inclui uma base purina e um grupo de açúcar, modificados para aumentar sua eficácia e estabilidade. Clofarabina exibe propriedades antineoplásicas ao interferir na síntese e reparo do DNA, levando à apoptose em células cancerosas. Seu mecanismo de ação envolve a inibição da DNA polimerase e da ribonucleotídeo redutase, que são cruciais para os processos de replicação e reparo do DNA. O composto é tipicamente administrado por via intravenosa e é conhecido por seus potenciais efeitos colaterais, incluindo mielossupressão, distúrbios gastrointestinais e infecções devido à imunossupressão. A farmacocinética de Clofarabina indica uma meia-vida relativamente curta, exigindo dosagem e monitoramento cuidadosos durante o tratamento. No geral, representa um avanço significativo nas terapias direcionadas ao câncer, particularmente para pacientes com leucemia em recaída ou refratária.

Fórmula: C₁₀H₁₁ClFN₅O₃

InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

Chave InChI: InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)=NC(Cl)=N1

Sinónimos:

• 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
• 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
• (2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
• 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
• 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
• 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
• Clolar
• 2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine
• 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
• CAFDA
• 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
• Clofarabine
• 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
• Clofarex
• (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol

Clofarabine

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 303.68

Ref: 3B-C2500

2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+%

CAS: 123318-82-1

A purine nucleoside anti-metabolite. Toxic to nondividing lymphocytes and monocytes This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item c

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 99+%

Peso molecular: 303.68

Ref: 02-J60927

Clofarabine

CAS: 123318-82-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₀H₁₁ClFN₅O₃

Cor e Forma: White Off-White Powder

Peso molecular: 303.05345

Ref: 45-1138620

Clofarabine System Suitability Mixture (This is a mixture containing clofarabine and clofarabine α anomer)

CAS: 123318-82-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Cor e Forma: White Solid

Ref: 45-1138621

(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 303.6774

Ref: IN-DA000KCJ

Clofarabine

CAS: 123318-82-1

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 99.94% - >99.99%

Cor e Forma: White Solid

Peso molecular: 303.68

Ref: TM-T0297

Clofarabine

CAS: 123318-82-1

Clofarabine

Pureza: ≥98%

Peso molecular: 303.68g/mol

Ref: 54-BUP15018

Clofarabine-13C-15N3

CAS: 123318-82-1

Fórmula: C₉₁₃CH₁₁ClFN₂₁₅N₃O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 307.65

Ref: 4Z-C-11508

Clofarabine

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Peso molecular: 303.68

Ref: 7W-GP5199

Clofarabine

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 303.68

Ref: 4Z-C-11501

Clofarabine, free base

CAS: 123318-82-1

Clofarabine, free base

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: By hplc: 99.9% (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 303.68g/mol

Ref: 54-BIFK0045

Clofarabine

Produto Controlado

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Cor e Forma: Neat

Peso molecular: 303.68

Ref: 86-MM3521.00

Clofarabine

CAS: 123318-82-1

Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),

Fórmula: C₁₀H₁₁ClFN₅O₃

Cor e Forma: White To Off-White

Peso molecular: 303.68

Ref: TR-C586890

Clofarabine

CAS: 123318-82-1

Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: Min. 98 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 303.68 g/mol

Ref: 3D-NA07154

Clofarabine - Bio-X ™

CAS: 123318-82-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 303.68 g/mol

Ref: 3D-BC300153

CLOFARABINE

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 303.68

Ref: 10-F387706