CAS 1234423-95-0

17-[[[3-[(4S)-6,8-dicloro-1,2,3,4-tetrahidro-2-metil-4-isoquinolinil]fenil]sulfonil]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dicloro-1,2,3,4-tetrahidro-2-metil-4-isoquinolinil]fenil]sulfonil]amino]etoxi]etoxi]etil]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamida

Descrição:

A substância química com o nome "17-[[[3-[(4S)-6,8-dicloro-1,2,3,4-tetrahidro-2-metil-4-isoquinolinil]fenil]sulfonil]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dicloro-1,2,3,4-tetrahidro-2-metil-4-isoquinolinil]fenil]sulfonil]amino]etoxi]etoxi]etil]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamida" e número CAS "1234423-95-0" é um composto orgânico complexo caracterizado por sua intrincada estrutura molecular, que inclui múltiplos grupos funcionais, como sulfonamidas, amidas e grupos oxo. A presença de moieties de dicloro e tetrahidroisoquinolina sugere uma potencial atividade biológica, possivelmente como um agente farmacêutico. Sua longa cadeia de carbono e múltiplas ligações éter indicam um grau de hidrofobicidade, o que pode influenciar sua solubilidade e biodisponibilidade. A complexidade estrutural do composto também pode sugerir interações específicas com alvos biológicos, tornando-o de interesse na química medicinal. No entanto, estudos detalhados seriam necessários para elucidar suas propriedades, incluindo estabilidade, reatividade e potenciais aplicações terapêuticas.

Fórmula: C₅₀H₆₆Cl₄N₈O₁₀S₂

InChI: InChI=1S/C50H66Cl4N8O10S2/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)58-14-18-70-22-24-72-20-16-60-74(67,68)40-10-6-8-36(26-40)44-32-62(2)34-46-42(44)28-38(52)30-48(46)54/h5-10,25-30,43-44,59-60H,3-4,11-24,31-34H2,1-2H3,(H2,55,57,63)(H2,56,58,64)/t43-,44-/m0/s1

Chave InChI: InChIKey=DNHPDWGIXIMXSA-CXNSMIOJSA-N

SMILES: ClC1=C2C([C@@H](CN(C)C2)C3=CC(S(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(=O)C4=CC(=CC=C4)[C@H]5C=6C(=C(Cl)C=C(Cl)C6)CN(C)C5)=O)=O)(=O)=O)=CC=C3)=CC(Cl)=C1

Sinónimos:

• 17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide
• Ibsrela
• AZD 1722
• Tenapanor
• 12,15-Dioxa-2,7,9-triazaheptadecanamide, 17-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-

Tenapanor

CAS: 1234423-95-0

Tenapanor

Pureza: ≥98%

Peso molecular: 1145.05g/mol

Ref: 54-BUP07081

Tenapanor

CAS: 1234423-95-0

Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.

Fórmula: C₅₀H₆₆Cl₄N₈O₁₀S₂

Pureza: 99.49% - 99.85%

Cor e Forma: Solid

Peso molecular: 1145.05

Ref: TM-T7587

Tenapanor (Butylene-D8)

Produto Controlado

CAS: 1234423-95-0

Fórmula: C₅₀D₈H₅₈Cl₄N₈O₁₀S₂

Cor e Forma: Neat

Peso molecular: 1153.098

Ref: TR-D436897

Tenapanor

Produto Controlado

CAS: 1234423-95-0

Fórmula: C₅₀H₆₆Cl₄N₈O₁₀S₂

Cor e Forma: Neat

Peso molecular: 1145.049

Ref: TR-T123440

Tenapanor

CAS: 1234423-95-0

Tenapanor is a novel antidiabetic drug that has been shown to be effective in the treatment of type 2 diabetes. Tenapanor (INN) reduces blood glucose levels by stimulating insulin release from pancreatic beta-cells and increasing insulin sensitivity in peripheral tissues. Tenapanor binds to the ATP-binding site of the phosphoinositide 3-kinase-related protein kinase 1 (PI3K1) enzyme, which is involved in glucose metabolism. It also inhibits phosphodiesterase 4D (PDE4D), an enzyme that degrades cyclic adenosine monophosphate (cAMP). This dual mechanism of action leads to increased insulin secretion and increased insulin sensitivity, which results in improved glycemic control.
Tenapanor has also been shown to improve long-term efficacy and reduce hypoglycemia when used as a pharmacological treatment for type 2 diabetes. The agent binds to ATP-binding sites on PI3K1, which prevents its

Fórmula: C₅₀H₆₆Cl₄N₈O₁₀S₂

Pureza: Min. 95%

Peso molecular: 1,145.04 g/mol

Ref: 3D-BT178667