CAS 123524-52-7

Azelnidipina

Descrição:

Azelnidipina é um bloqueador de canais de cálcio usado principalmente no tratamento da hipertensão. Pertence à classe de compostos dihidropiridínicos, que se caracterizam pela sua capacidade de inibir a entrada de cálcio através dos canais de cálcio tipo L no músculo liso vascular e no tecido cardíaco. Essa ação leva à vasodilatação e a uma subsequente redução da pressão arterial. Azelnidipina é conhecido por sua longa meia-vida, permitindo uma dosagem uma vez ao dia, o que melhora a adesão do paciente. O composto exibe seletividade por tecidos vasculares em relação aos tecidos cardíacos, minimizando potenciais efeitos colaterais, como taquicardia reflexa. Além disso, possui propriedades antioxidantes, que podem proporcionar benefícios cardiovasculares adicionais. Azelnidipina é tipicamente administrado em sua forma de sal hidroclorídrico e é bem absorvido no trato gastrointestinal. Sua farmacocinética pode ser influenciada pela ingestão de alimentos, e é metabolizado principalmente no fígado. No geral, Azelnidipina representa uma opção valiosa na terapia antihipertensiva, particularmente para pacientes que necessitam de manejo a longo prazo da hipertensão arterial alta.

Fórmula: C₃₃H₃₄N₄O₆

InChI: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

Chave InChI: InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N

SMILES: C(OC1CN(C(C2=CC=CC=C2)C3=CC=CC=C3)C1)(=O)C=4C(C(C(OC(C)C)=O)=C(C)NC4N)C5=CC(N(=O)=O)=CC=C5

Sinónimos:

• 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
• 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3-[1-(Diphenylmethyl)Azetidin-3-Yl] 5-Propan-2-Yl 2-Amino-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• Calblock
• Ccris 8650
• Cs 905
• Unii-Pv23P19Yug

3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 582.6463

Ref: IN-DA000KQ9

Azelnidipine

CAS: 123524-52-7

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

Fórmula: C₃₃H₃₄N₄O₆

Pureza: 99.78%

Cor e Forma: Light Yellowish Powder

Peso molecular: 582.65

Ref: TM-T0121

Azelnidipine

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Cor e Forma: Light Yellow Solid

Peso molecular: 582.66

Ref: 4Z-A-10101

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Pureza: ≥98%

Peso molecular: 582.65g/mol

Ref: 54-BUP13584

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Pureza: 99%

Peso molecular: 582.65g/mol

Ref: 54-OR1028132

Azelnidipine-d7

CAS: 123524-52-7

Fórmula: C₃₃H₂₇D₇N₄O₆

Cor e Forma: Yellow Solid

Peso molecular: 589.70

Ref: 4Z-A-10102

Azelnidipine

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light orange to Yellow to Green powder to crystal

Peso molecular: 582.66

Ref: 3B-A2433

Azelnidipine

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: Off-white to light yellow powder

Peso molecular: 582.65

Ref: 7W-GP5829

Azelnidipine

CAS: 123524-52-7

Azelnidipine is a drug that is used to treat high blood pressure and heart disease. It reduces the risk of cardiovascular events such as myocardial infarction and stroke. Azelnidipine has been shown to have an antioxidative effect, which may be due to its ability to decrease lipid peroxidation, increase superoxide dismutase activity, and inhibit the production of reactive oxygen species in a model of tubulointerstitial injury. The drug also inhibits calcium influx into cells by interfering with voltage-gated calcium channels. Azelnidipine binds reversibly to α1-acid glycoprotein, which is found in plasma and erythrocytes. This interaction may result in changes in renal function when combined with other drugs that bind the same protein (e.g., warfarin).

Fórmula: C₃₃H₃₄N₄O₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 582.65 g/mol

Ref: 3D-FA18072

Azelnidipine

Produto Controlado

CAS: 123524-52-7

Applications Azelnidipine is a dihydropyridine calcium channel blocker with antihypertensice activity. Azelnidipine is used for treating ischemic heart disease and cardiac remodeling after myocardial infarction. Studies show that Azelnidipine ttreatment can reduce the risk of hyperglycemia induced metabolic disorders
References Sugimoto, K. et al.: Int. J. Hypertens., No pp. (2010); Kain, V. et al.: Cardio. Diabetol., 9, 82 (2010); Kinouchi, K. et al.: Int. J. Hypertens., 284823, 11 (2011);

Fórmula: C₃₃H₃₄N₄O₆

Cor e Forma: Yellow

Peso molecular: 582.65

Ref: TR-A808500