CAS 123884-00-4

Dolastatina 15

Descrição:

Dolastatina 15 é um peptídeo potente derivado do molusco marinho Dolabella auricularia, conhecido por suas significativas propriedades antitumorais. Este composto é caracterizado por sua estrutura complexa, que inclui uma série de aminoácidos que contribuem para sua atividade biológica. Dolastatina 15 exibe um mecanismo de ação único, principalmente inibindo a montagem de microtúbulos, interrompendo assim a formação do fuso mitótico durante a divisão celular. Essa ação o torna um candidato para o tratamento do câncer, particularmente visando vários tipos de tumores. A substância também é notada por sua alta potência e especificidade, o que pode levar a efeitos colaterais reduzidos em comparação com agentes quimioterapêuticos tradicionais. Além disso, Dolastatina 15 tem sido objeto de extensa pesquisa para explorar seu potencial no desenvolvimento de medicamentos, embora sua aplicação clínica ainda esteja sob investigação. Sua estabilidade, solubilidade e biodisponibilidade são fatores críticos que influenciam sua eficácia terapêutica e formulação em contextos farmacêuticos. No geral, Dolastatina 15 representa uma avenida promissora na busca por terapias eficazes contra o câncer.

Fórmula: C₄₅H₆₈N₆O₉

InChI: InChI=1/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1

SMILES: CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc2)C(=CC1=O)OC)N=C([C@H](C(C)C)N(C)C)O

Sinónimos:

• (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• (2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl N-methyl-L-valyl-L-prolyl-2-{(2S)-2-[(N,N-dimethyl-L-valyl)amino]-3-methylbutanoyl}-L-prolinate
• 1-(2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl N,N-dimethylvalylvalyl-N-methylvalylprolylprolinate
• (1S)-1-{[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}-2-methylpropyl N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinate
• DOLASTATIN 15
• L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
• L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
• Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• (5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
• (5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one
• Nsc 617668

Dolastatin 15

CAS: 123884-00-4

Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED₅₀ value of 2.4 ng/mL.

Fórmula: C₄₅H₆₈N₆O₉

Pureza: 98.7%

Cor e Forma: White Powder

Peso molecular: 837.07

Ref: 01-4019226

L-Proline, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester

CAS: 123884-00-4

Fórmula: C₄₅H₆₈N₆O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 837.0562

Ref: IN-DA000L75

Dolastatin 15

CAS: 123884-00-4

Dolastatin 15, depsipeptide from Dolabella auricularia, is an ADC cytotoxin that induces apoptosis in myeloma cells.

Fórmula: C₄₅H₆₈N₆O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 837.072

Ref: TM-T15158

Dolastatin 15

CAS: 123884-00-4

Fórmula: C₄₅H₆₈N₆O₉

Pureza: ≥ 95.0%

Cor e Forma: White powder

Peso molecular: 837.06

Ref: 7W-GP8277

Dolastatin 15

Produto Controlado

CAS: 123884-00-4

Fórmula: C₄₅H₆₈N₆O₉

Cor e Forma: Neat

Peso molecular: 837.056

Ref: TR-D528508

Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline

CAS: 123884-00-4

Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzylpyrrolidinium is a natural compound that has been isolated from the Indian Ocean sea hare Dolabella auricularia. It has shown significant cytotoxicity against cancer cells as well as significant immunosuppressive activities in animals. Dolastatin 15 is an analog of dolastatin 10 and has been shown to be active against hepatitis B and C virus. It also has antiinflammatory properties and may be effective in combating autoimmune diseases. The synthesis of this compound is an asymmetric synthesis with a hydroxyl group on one side of the molecule and an amide on the other side.

Fórmula: C₄₅H₆₈N₆O₉

Pureza: Min. 95%

Peso molecular: 837.06 g/mol

Ref: 3D-FD110329