CAS 124584-08-3

Peptídeo natriurético cerebral-32 (humano)

Descrição:

O peptídeo natriurético cerebral (BNP) é uma neuro-hormona produzida principalmente nos ventrículos cardíacos em resposta à expansão do volume ventricular e à sobrecarga de pressão. A forma específica conhecida como peptídeo natriurético cerebral-32 (humano) é um peptídeo de 32 aminoácidos que desempenha um papel crucial na homeostase cardiovascular. Funciona promovendo a natriurese, diurese e vasodilatação, ajudando assim a regular a pressão arterial e o equilíbrio de fluidos. O BNP está envolvido na fisiopatologia da insuficiência cardíaca, e seus níveis no sangue podem servir como um biomarcador para diagnosticar e gerenciar essa condição. O número CAS 124584-08-3 identifica este peptídeo específico, que é caracterizado por seu tamanho relativamente pequeno e sequência específica de aminoácidos que o distingue de outros peptídeos natriuréticos. Sua atividade biológica é mediada pela ligação a receptores específicos, levando a vários efeitos fisiológicos, incluindo a inibição do sistema renina-angiotensina-aldosterona. No geral, o BNP é significativo tanto em ambientes clínicos quanto de pesquisa, particularmente em cardiologia.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Sinónimos:

• Natriureticfactor-32 (human brain clone lhBNP57)
• 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane,cyclic peptide deriv.
• 1: PN:US6028055 SEQID: 1 claimed protein
• 6: PN:US20090011997 SEQID: 4 claimed protein
• 83: PN: US20080153747 SEQID: 83 claimedprotein
• Human brain natriuretic factor-32
• Human brain natriuretic peptide-32
• L-Histidine,L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-a-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-,cyclic (10?
• 26)-Disulfide
• Natriureticpeptide type-B
• Nesiritide

BNP-32 (human)

CAS: 124584-08-3

Bachem ID: 4095916.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: 97.9%

Cor e Forma: White

Peso molecular: 3464.09

Ref: 01-4095916

BNP-32 (human)

CAS: 124584-08-3

The secretion of the cardiac hormone BNP-32 is increased considerably in patients with congestive heart failure, successful medical treatment of this condition will result in a decrease. Yandle et al. described a method for determining hBNP in human plasma. Effects of hBNP infusion in humans have been described by Holmes et al and La Villa et al. BNP is an important biomarker in the diagnosis of heart diseases. Additionally, BNP-32 may act as a neuropeptide. BNP-32 exerts strong lipolytic effects in humans.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: 97.8%

Peso molecular: 3464.09

Ref: 01-4049848

BNP-32 (human)

CAS: 124584-08-3

The secretion of the cardiac hormone BNP-32 is increased considerably in patients with congestive heart failure, successful medical treatment of this condition will result in a decrease. Yandle et al. described a method for determining hBNP in human plasma. Effects of hBNP infusion in humans have been described by Holmes et al and La Villa et al. BNP is an important biomarker in the diagnosis of heart diseases. Additionally, BNP-32 may act as a neuropeptide. BNP-32 exerts strong lipolytic effects in humans.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: 97.2%

Cor e Forma: White

Peso molecular: 3464.09

Ref: 01-4016567

Nesiritide

CAS: 124584-08-3

Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 3464.04

Ref: TM-TP1208

Brain Natriuretic Peptide-32 human

CAS: 124584-08-3

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Peso molecular: 3464.03

Ref: 7W-GP2071

BNP-32 (Human)

CAS: 124584-08-3

BNP-32 is a peptide that has been shown to activate G-protein coupled receptors and ion channels. It is known to be an agonist of the receptor for bradykinin and vasoactive intestinal peptide, as well as the receptor for neurotensin, which is a member of the tachykinin family. BNP-32 can also inhibit ligand binding to some receptors, such as those for calcitonin gene-related peptide (CGRP) and substance P (SP). BNP-32 has been used as a research tool in cell biology and pharmacology.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: Min. 95%

Peso molecular: 3,464.05 g/mol

Ref: 3D-PBN-4212-V

BNP-32 human

CAS: 124584-08-3

This 32 amino acid peptide contains a 17 amino acid ring structure that is common to all natriuretic peptides. It is also called the brain natriuretic peptide (BNP) because it was first identified in porcine brain- however, the main source of this peptide is not the brain but the cardiac ventricle. This cardiac neurohormone is secreted from the ventricles in response to volume expansion and pressure overload. It has natriuretic and vasodilatory effects and suppresses the renin-angiotensin-aldosterone system.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Cor e Forma: Powder

Peso molecular: 3,463.8 g/mol

Ref: 3D-CRB1000505

BNP-32 (human)

CAS: 124584-08-3

Natriuretic; vasodilatory;diuretic; treats decompensated congestive hear failure

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 3,464.04 g/mol

Ref: 3D-FB110377

Nesiritide acetate

CAS: 124584-08-3

Nesiritide acetate is a man-made form of the natriuretic peptide hormone that is secreted by the heart. It is used to treat high blood pressure and congestive heart failure. Nesiritide acetate increases the amount of sodium and water excreted from the body, which reduces blood volume and lowers blood pressure. It also relaxes blood vessels, leading to lower blood pressure. This drug can also be used in diagnosis to assess levels of natriuretic peptides in the bloodstream. The typical therapeutic dose for this drug is 100 mcg/kg given intravenously over 30 minutes and then infusion at 0.01 mcg/kg/min for up to 24 hours. The dosage may be increased or decreased depending on the severity of symptoms or side effects experienced by the patient.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄•(C₂H₄O₂)x

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 3,464.05 g/mol

Ref: 3D-FN41185

BNP-32 (human) hydrochloride

CAS: 124584-08-3

BNP-32 is a peptide hormone that regulates the volume of blood in the heart and lungs. It is used to diagnose congestive heart failure, and also as a treatment for decompensated congestive heart failure. When given as an intravenous infusion, BNP-32 reduces the levels of natriuretic peptides in the blood stream by increasing their breakdown in the kidneys. The disulfide bond between cysteine residues (Cys-Cys) is essential for its activity. BNP-32 has been shown to be effective against infectious diseases such as HIV, hepatitis C, and tuberculosis. It is also used in combination with other drugs to treat high blood pressure. This drug can be administered orally or intravenously and is biocompatible with human tissue because it is chemically stable and non-toxic at therapeutic doses.

Fórmula: C₁₄₃H₂₄₄N₅₀O₄₂S₄

Pureza: Min. 95%

Peso molecular: 3,464.04 g/mol

Ref: 3D-FB110257