CAS 125-65-5

Pleuromutilina

Descrição:

Pleuromutilina é um antibiótico natural derivado do fungo *Pleurotus mutilus*. Pertence à classe de compostos conhecidos como Pleuromutilinas, que se caracterizam por sua estrutura única que inclui um sistema de anel tetracíclico. Este antibiótico exibe atividade de amplo espectro contra várias bactérias Gram-positivas e algumas bactérias Gram-negativas, tornando-o eficaz no tratamento de infecções causadas por cepas resistentes. Pleuromutilina funciona inibindo a síntese de proteínas bacterianas, direcionando-se especificamente ao centro de transferência peptidílica do ribossomo, o que interrompe o processo de tradução. Seu baixo perfil de toxicidade e eficácia levaram ao seu desenvolvimento para uso clínico, particularmente no tratamento de infecções de pele e tecidos moles. Além disso, Pleuromutilina foi modificado para criar derivados semissintéticos, como a retapamulina, que são usados em formulações tópicas. A substância é tipicamente administrada de maneira controlada, e sua farmacocinética é influenciada por fatores como formulação e via de administração. No geral, Pleuromutilina representa um avanço significativo na terapia antibiótica, especialmente diante do aumento da resistência aos antibióticos.

Fórmula: C₂₂H₃₄O₅

InChI: InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1

Chave InChI: InChIKey=ZRZNJUXESFHSIO-BKUNHTPHSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CO)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Sinónimos:

• (3aS,4R,5S,6S,8R,9S,9aR,10S)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
• 14-Deoxy-14-[(hydroxyacetyl)oxy]mutilin
• 3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
• 6-Ethenyl-5-Hydroxy-4,6,9,10-Tetramethyl-1-Oxodecahydro-3A,9-Propanocyclopenta[8]Annulen-8-Yl Hydroxyacetate
• Acetic acid, 2-hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα,4β,5α,6α,8β,9α,9aβ,10S*)]-
• Antibiotic A 40104C
• Bc 757
• Drosophilin B
• Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1(4H)-one
• Mutilin 14-glycolate
• NSC 121145

Pleuromutilin

CAS: 125-65-5

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 378.509

Ref: 10-F987727

VALNEMULIN IMPURITY E CRS

CAS: 125-65-5

VALNEMULIN IMPURITY E CRS

Fórmula: C₂₂H₃₄O₅

Peso molecular: 378.5024

Ref: 41-Y0000586

Acetic acid, hydroxy-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 378.5024

Ref: IN-DA00HHVG

Pleuromutilin

CAS: 125-65-5

Pleuromutilin

Pureza: ≥98%

Peso molecular: 378.5g/mol

Ref: 54-BUP14420

Tiamulin EP Impurity G (Valnemulin EP Impurity E)

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Peso molecular: 378.51

Ref: 4Z-T-9410

Pleuromutilin

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Pureza: ≥ 95.0%

Cor e Forma: White to off-white or light yellow solid

Peso molecular: 378.5

Ref: 7W-GA2930

(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl Hydroxyacetate (Pleuromutilin)

Produto Controlado

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Cor e Forma: Neat

Peso molecular: 378.50

Ref: 86-MM0394.10

Pleuromutilin

CAS: 125-65-5

Pleuromutilin (Drosophilin B) is an inhibitor of bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

Fórmula: C₂₂H₃₄O₅

Pureza: 97.321%

Cor e Forma: Crystalline Solid

Peso molecular: 378.5

Ref: TM-T16552

Pleuromutilin

Produto Controlado

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Cor e Forma: Neat

Peso molecular: 378.50

Ref: TR-P610500

Pleuromulin

CAS: 125-65-5

The compound 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate is an antimicrobial agent that inhibits bacterial growth by binding to the disulfide bond of bacterial peptidoglycan. It is effective against a wide range of microorganisms including MRSA and methicillin resistant Enterococcus faecalis. The compound has shown efficacy in an animal model of chronic bronchitis caused by Streptococcus pneumoniae. The compound has a short half life and can be administered orally or intravenously with a pharmacokinetic profile that depends on the dose. This drug also has high resistance to β lactamase enzymes, which are found in some bacteria such as E. coli.

Fórmula: C₂₂H₃₄O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 378.5 g/mol

Ref: 3D-FP27100

Pleuromulin - Bio-X ™

CAS: 125-65-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₂H₃₄O₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 378.5 g/mol

Ref: 3D-BH300113

Tiamulin EP Impurity G

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Peso molecular: 378.51

Ref: ST-EA-CP-T154005