CAS 125317-39-7

Navelbine

Descrição:

Navelbine, conhecido pelo seu nome genérico vinorelbine, é um alcaloide de vinca semissintético derivado da planta de pervinca, Catharanthus roseus. É utilizado principalmente como agente quimioterápico no tratamento de vários tipos de câncer, incluindo câncer de pulmão de células não pequenas e câncer de mama. Vinorelbine atua inibindo a formação de microtúbulos durante a divisão celular, interrompendo assim o fuso mitótico e levando à parada do ciclo celular e apoptose em células cancerosas que se dividem rapidamente. O composto é tipicamente administrado por via intravenosa e possui um perfil de efeitos colaterais moderado, que pode incluir neutropenia, náuseas e fadiga. Sua farmacocinética envolve metabolismo hepático, principalmente através do sistema do citocromo P450, e é excretado principalmente na bile. O número CAS 125317-39-7 identifica de forma única a vinorelbine em bancos de dados químicos, facilitando a pesquisa e aplicações clínicas. No geral, Navelbine representa uma opção terapêutica importante em oncologia, contribuindo para a melhoria dos resultados em pacientes com malignidades específicas.

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

InChI: InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

Chave InChI: InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H].[C@@H]([C@H](C(O)=O)O)(C(O)=O)O

Sinónimos:

• (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
• 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
• 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
• 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
• 5'-Noranhydrovinoblastine Tartrate
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Bitartrate
• Butanedioate(1:2)
• C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
• Kw 2307
• Navelbine
• Navelbine ditartrate
• Navelbine tartrate
• Nor-5′-anhydrovinblastine ditartrate
• Nvb
• Pacilitaxel
• Vinorelbin
• Vinorelbine bitartrate
• Vinorelbine bitratrate
• Vinorelbine ditartaric acid
• Vinorelbine ditartrate salt
• Vinorelbine tartarate
• Vinorelbine tartrate
• Vinorelbine tartrate usp standard
• Vinorelbineditartrate salt hydrate
• [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)

VINORELBINE TARTRATE CRS

CAS: 125317-39-7

VINORELBINE TARTRATE CRS

Fórmula: C₄₅H₅₄N₄O₈

Cor e Forma: Powder

Peso molecular: 778.9323

Ref: 41-Y0000463

VINORELBINE FOR PEAK IDENTIFICATION A CRS

CAS: 125317-39-7

VINORELBINE FOR PEAK IDENTIFICATION A CRS

Cor e Forma: Powder

Ref: 41-Y0001938

VINORELBINE FOR PEAK IDENTIFICATION B CRS

CAS: 125317-39-7

VINORELBINE FOR PEAK IDENTIFICATION B CRS

Cor e Forma: Powder

Ref: 41-Y0001939

Vinorelbine Tartrate

CAS: 125317-39-7

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Cor e Forma: Powder

Peso molecular: 778.39416

Ref: 45-1714506

Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

CAS: 125317-39-7

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 1079.1059

Ref: IN-DA00HI66

Vinorelbine Ditartrate Salt

CAS: 125317-39-7

Vinorelbine Ditartrate Salt

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: 98%

Cor e Forma: white to off-white solid

Peso molecular: 1,079.11g/mol

Ref: 54-BIFK0008

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Cor e Forma: White To Off-White Solid

Peso molecular: 778.95 2*150.09

Ref: 4Z-V-040001

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate

Pureza: ≥98%

Peso molecular: 1079.11g/mol

Ref: 54-BUP13274

Vinorelbine Tartrate

Produto Controlado

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆

Cor e Forma: Neat

Peso molecular: 1079.11

Ref: 86-MM1252.00

Vinorelbine tartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆

Cor e Forma: Neat

Peso molecular: 1079.11

Ref: 04-CA17921850

Vinorelbine Tartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈•2C₄H₆O₆

Pureza: 95%~99%

Peso molecular: 1079.11

Ref: BP-BP1446

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: >95.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 1,079.12

Ref: 3B-V0151

Vinorelbine ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆·xH₂O

Pureza: (HPLC) ≥ 98.0% (dried basis)

Cor e Forma: White to off-white powder

Peso molecular: 1079.11 (anhydrous)

Ref: 7W-GP5205

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity. Cost-effective and quality-assured.

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: 98% - 99.86%

Cor e Forma: White To Off-White Crystalline Powder

Peso molecular: 1079.11

Ref: TM-T6213

Vinorelbine-d3 Bitartrate

Produto Controlado

CAS: 125317-39-7

Stability Light Sensitive, Temperature Sensitive
Applications An antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Fórmula: C₅₃H₆₃D₃N₄O₂₀

Cor e Forma: Neat

Peso molecular: 1082.12

Ref: TR-V315002

Vinorelbine Bitartrate

Produto Controlado

CAS: 125317-39-7

Stability Temperature Sensitive
Applications An antineoplastic.
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Cor e Forma: White

Peso molecular: 1079.11

Ref: TR-V315000

Vinorelbine tartrate - Bio-X ™

Produto Controlado

CAS: 125317-39-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,079.11 g/mol

Ref: 3D-BV300138

Vinorelbine tartrate

Produto Controlado

CAS: 125317-39-7

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: (Hplc) Min. 98.0%

Cor e Forma: White Powder

Peso molecular: 1,079.11 g/mol

Ref: 3D-FV61484

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈(C₄H₆O₆)

Peso molecular: 778.95 : 2(150.09)

Ref: ST-EA-CP-V49001