CAS 125354-16-7

N-Debenzoil-N-(tert-butoxicarbonil)taxol

Descrição:

N-Debenzoil-N-(tert-butoxicarbonil)taxol, identificado pelo seu número CAS 125354-16-7, é um derivado do conhecido agente quimioterápico paclitaxel (Taxol). Este composto apresenta uma estrutura modificada que inclui um grupo tert-butoxicarbonilo (Boc) e uma modificação debenzoílica, que altera suas propriedades farmacológicas. A presença do grupo Boc melhora a estabilidade e solubilidade do composto, tornando-o mais adequado para várias reações químicas e aplicações potenciais em sistemas de entrega de medicamentos. O processo de debenzoilação pode influenciar a interação do composto com alvos biológicos, afetando potencialmente sua eficácia e perfil de toxicidade. Como um intermediário sintético, pode ser utilizado no desenvolvimento de novos agentes anticancerígenos ou em pesquisas focadas em melhorar o índice terapêutico dos derivados do taxol. No geral, N-Debenzoil-N-(tert-butoxicarbonil)taxol representa uma modificação significativa da estrutura do taxol, visando melhorar suas propriedades farmacêuticas enquanto mantém sua atividade anticancerígena central.

Fórmula: C₄₅H₅₅NO₁₅

InChI: InChI=1/C45H55NO15/c1-23-28(58-39(53)33(50)32(26-16-12-10-13-17-26)46-40(54)61-41(4,5)6)21-45(55)37(59-38(52)27-18-14-11-15-19-27)35-43(9,29(49)20-30-44(35,22-56-30)60-25(3)48)36(51)34(57-24(2)47)31(23)42(45,7)8/h10-19,28-30,32-35,37,49-50,55H,20-22H2,1-9H3,(H,46,54)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

Sinónimos:

• (2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• benzenepropanoic acid, beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Acetyltaxotere
• Docetaxal
• 10-Acetyldocetaxel
• Docetaxel Impurity 7(Docetaxel EP Impurity G)
• Docetaxel impurity G
• Docetaxel EP Impurity G (10-Acetyl Docetaxel)
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,...
• CS-878
• DOCETAXOL
• Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
• ACETYLDOCETAXEL, 10-(P)
• Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode
• Docetaxel EP Impurity G
• N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
• (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate
• PNU 101383

Docetaxal

CAS: 125354-16-7

Docetaxal (10-Acetyl docetaxel) is an analogue of Docetaxel, which is a microtubule inhibitor. Docetaxal can be used in cancer research.

Fórmula: C₄₅H₅₅NO₁₅

Cor e Forma: Solid

Peso molecular: 849.92

Ref: TM-T38644

Docetaxel EP Impurity G (10-Acetyl Docetaxel)

CAS: 125354-16-7

Fórmula: C₄₅H₅₅NO₁₅

Cor e Forma: White To Off-White Solid

Peso molecular: 849.93

Ref: 4Z-D-195

Docetaxal

CAS: 125354-16-7

Docetaxal

Pureza: 98%

Peso molecular: 849.92g/mol

Ref: 54-OR1035876

Docetaxal

Produto Controlado

CAS: 125354-16-7

Impurity Docetaxel EP Impurity G
Applications Docetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.
References Zhu, Q.Q., et al.: J. Med. Chem., 40, 4319 (1997); Burkhart, C.A., et al.: Cancer. Res., 54, 5779 (1994); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Fórmula: C₄₅H₅₅NO₁₅

Cor e Forma: Neat

Peso molecular: 849.92

Ref: TR-D494565

Docetaxal-d9

Produto Controlado

CAS: 125354-16-7

Fórmula: C₄₅D₉H₄₆NO₁₅

Cor e Forma: Neat

Peso molecular: 858.971

Ref: TR-D494567

Docetaxel EP Impurity G

CAS: 125354-16-7

Fórmula: C₄₅H₅₅NO₁₅

Peso molecular: 849.87

Ref: ST-EA-CP-D32007

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

CAS: 125354-16-7

Fórmula: C₄₅H₅₅NO₁₅

Cor e Forma: Solid

Peso molecular: 849.9159

Ref: IN-DA000NIQ